Multicentre Study on Diabetic Foot Treatment (MSDFT)

Inclusion Criteria: Symptoms: Wagner stage 2 or above foot ulcer (deep ulcer, abscess or osteomyelitis; localized gangrene, characterized by ischemic gangrene, usually with neuropathy; gangrene of the whole foot), may be accompanied by chronic limb pain, intermittent claudication, cold sensation, abnormal skin sensation and other symptoms Have not taken reserpine in the past week or can change to other antihypertensive drugs Voluntary participation and signing of informed consent Exclusion Criteria: Patients with organ failure diagnosed by doctors in the past: such as heart failure, liver and kidney failure Patients with myocardial infarction diagnosed by doctors in the past With congenital or acquired organic heart disease With basic disease is in the active stage, such as newly diagnosed leukemia patients, or leukemia patients with relapse and refractory Active infection: pulmonary infection, intestinal infection and other existing infections Severe anemia Severe osteoporosis Have undergone amputation of both lower limbs The investigator judged that it was not suitable to participate in this study, including the existence of abnormal laboratory test results or clinical abnormal symptoms/signs There are any of the following conditions that may limit the patient's compliance or hinder data collection: dementia; Serious mental disorder, unable to express will; Unable to complete the research evaluation as required Other contraindications of anesthesia or surgery