Innovative Imaging and Cognitive BIOmarkers to Predict Huntington's Disease Progression (I2BIO-HD)

Inclusion Criteria: For all participants: Age ≥18 years and ≤65 years Information and collection of written consent Affiliation with a social security plan, beneficiary or beneficiary's right Healthy controls UHDRS functional score TFC = 13 Motor UHDRS score TMS < 6 With no known genetic disease and no direct relationship to an HD patient or family ancestors carrying the HD mutation (or knowing their genetic status with CAG < 36). Manifest carriers Number of GACs ≥ 40 CAP score ≥ 250 10 ≤ TFC ≤ 13 TMS >5 if TFC=13 Diagnostic confidence level =4 Age of onset of disease > 20 years Patients physically able to sign consent Premanifest carriers Number of GACs ≥ 40 CAP score ≥250 CFT = 13 TMS < 6 Patients physically able to sign consent Exclusion Criteria: Participant under guardianship or curatorship Neurological or psychiatric disorder unrelated to HD Intercurrent illness that may impact participant's performance Chronic progressive neurological disease Claustrophobia Brain injury unrelated to HD Pacemaker, intracorporeal metal, intracerebral clip, any metallic foreign body: implantable cardiac electronic device such as pacemakers, implantable cardioverter defibrillators etc., metallic intraocular foreign bodies, implantable neurostimulation systems, cochlear implants/ear implants, drug infusion pumps (insulin administration, analgesic drugs), or chemotherapy pumps): if possible, the patient should remove the device. Catheters with metal components (Swan-Ganz catheter), metal fragments such as bullets, shotgun pellets and metal shrapnel, cerebral artery aneurysm clips, magnetic dental implants, tissue expander, artificial limb, hearing aid, piercing such as pacemaker, Known hypersensitivity to the radiopharmaceutical preparation (excipients in the radiopharmaceutical preparation) Pregnant or breastfeeding woman Person under state medical aid Person deprived of liberty Person participating or having participated in an interventional study for less than 3 months or without time limit in a trial of neural transplants or gene therapy. Person participating or having participated in a research protocol with a radiopharmaceutical injection for less than 12 months. Neurological or psychiatric disorder unrelated to HD Intercurrent disease that may impact participant's performance Chronic progressive neurological disease Claustrophobia Brain injury unrelated to HD Pacemaker, intracorporeal metal, intracerebral clip Pregnant, breastfeeding or wanting to procreate during participation in the study.