Comparing the Efficacy and Safety of Finerenone and Spironolactone in the Treatment of Primary Aldosteronism
Primary Aldosteronism, Hypertension
About this trial
This is an interventional treatment trial for Primary Aldosteronism focused on measuring primary aldosteronism, hypertension, finerenone, spironolactone, treatment
Eligibility Criteria
Inclusion Criteria: 1.Age: 18-75 years old. 2.History of hypertension, DBP <120 mmHg, SBP <180 mmHg. 3.Serum potassium level ≥ 2.5 mmol/L. 4.Primary Aldosteronis diagnosed by increased aldosterone renin ratio (ARR) > 30 ng/dl: ng/ml/h, and serum aldosterone levels ≥15 ng / dl, and confirmed by captopril inhibition test. Exclusion Criteria: 1. Abnormal renal function: serum creatinine ≥ 2 × ULN or eGFR ≤ 60 ml/(min * 1.73m2); 2. Abnormal liver function: ALT and AST ≤ 2.5 × ULN, TBIL ≤ 1.5 × ULN; 3. Cardiac insufficiency, acute myocardial infarction, stroke or other acute cardiovascular events within 6 months; 4. Take spironolactone, guanethidine or reserpine 30 days before enrollment; 5. Known or suspected tumor; Other autoimmune diseases, uncontrolled infectious diseases, serious respiratory, blood and nervous system diseases; 6. There is a pregnancy plan in pregnancy or 3 months before and after treatment. Breast-feeding women; 7. Those who have mental illness, alcohol or drug abuse and cannot cooperate with treatment.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Finerenone
Spironolactone