Back to resultsEffects of COP Exercise and HIIT on Vascular Health in Young Overweight Females
Primary Purpose
Vascular Diseases
Status
Completed
Phase
Not Applicable
Locations
China
Study Type
Interventional
Intervention
high-intensity interval training (HIIT)
crossover point(COP) exercise training
Sponsored by
About this trial
This is an interventional prevention trial for Vascular Diseases
Eligibility Criteria
Inclusion Criteria: Female, 18-30 years old Body mass index (BMI) < 28 kg/m2 and ≥ 24 kg/m2 No exercise habit, and no recent new exercise plan No contraindications to exercise Exclusion Criteria: Participates had an orthopedic or other condition that limited participation in daily exercise Participates had a history of myocardial infarction, stroke, diabetes mellitus, chronic respiratory disease or cancer Participates had smoking or alcohol behavior
Sites / Locations
- Beijing Sport University
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Experimental
Arm Label
HIIT group
COP group
Arm Description
Outcomes
Primary Outcome Measures
brachial-ankle pulse wave velocity (baPWV)
The change of baPWV before and after intervention
blood pressure
The change of blood pressure before and after intervention
Secondary Outcome Measures
Interleukin 6 (IL-6)
The change of IL-6 level before and after intervention
Homocysteine (HCY)
The change of HCY level before and after intervention
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT05817487
Brief Title
Effects of COP Exercise and HIIT on Vascular Health in Young Overweight Females
Official Title
Effects of Crossover Point Exercise and High-intensity Interval Training on Vascular Health in Young Overweight Females
Study Type
Interventional
2. Study Status
Record Verification Date
April 2023
Overall Recruitment Status
Completed
Study Start Date
February 18, 2019 (Actual)
Primary Completion Date
July 5, 2019 (Actual)
Study Completion Date
October 25, 2019 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Beijing Sport University
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
5. Study Description
Brief Summary
The goal of this study is to determine the effects of high-intensity interval training and crossover point exercise training on vascular health in young overweight women.
Detailed Description
In recent years, improving cardiovascular health through exercise has become a popular research question, however, it is not clear which intensity and modes of exercise bring more benefits. Crossover point(COP) intensity has great medical potential as a personalized exercise intensity that is based on substrate utilization mode, especially in overweight and obese people.On the other hand, several studies have demonstrated that HIIT is an effective method in improving vascular endothelial dysfunction. During our study, we evaluated the vascular health changes in young overweight women who received either COP exercise or HIIT exercise for 10 weeks.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Vascular Diseases
7. Study Design
Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
20 (Actual)
8. Arms, Groups, and Interventions
Arm Title
HIIT group
Arm Type
Experimental
Arm Title
COP group
Arm Type
Experimental
Intervention Type
Behavioral
Intervention Name(s)
high-intensity interval training (HIIT)
Intervention Description
Participants in both the COP and HIIT groups underwent 30 sessions of exercise performed over 10 weeks. The training sessions in the HIIT group involved five high-intensity intervals of 4 minutes each (running or walking on a treadmill) at 85% VO2max interspersed with 3 minutes of low-intensity walking.
Intervention Type
Behavioral
Intervention Name(s)
crossover point(COP) exercise training
Intervention Description
Participants in both the COP and HIIT groups underwent 30 sessions of exercise performed over 10 weeks. The COP exercise training sessions involved 45 minutes of continuous exercise at the COP on a treadmill.
Primary Outcome Measure Information:
Title
brachial-ankle pulse wave velocity (baPWV)
Description
The change of baPWV before and after intervention
Time Frame
10 weeks
Title
blood pressure
Description
The change of blood pressure before and after intervention
Time Frame
10 weeks
Secondary Outcome Measure Information:
Title
Interleukin 6 (IL-6)
Description
The change of IL-6 level before and after intervention
Time Frame
10 weeks
Title
Homocysteine (HCY)
Description
The change of HCY level before and after intervention
Time Frame
10 weeks
10. Eligibility
Sex
Female
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
30 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Female, 18-30 years old
Body mass index (BMI) < 28 kg/m2 and ≥ 24 kg/m2
No exercise habit, and no recent new exercise plan
No contraindications to exercise
Exclusion Criteria:
Participates had an orthopedic or other condition that limited participation in daily exercise
Participates had a history of myocardial infarction, stroke, diabetes mellitus, chronic respiratory disease or cancer
Participates had smoking or alcohol behavior
Facility Information:
Facility Name
Beijing Sport University
City
Beijing
Country
China
12. IPD Sharing Statement
Learn more about this trial
Effects of COP Exercise and HIIT on Vascular Health in Young Overweight Females
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