Treatment of Gingival Recession Defects Using Platelet-Rich Fibrin With an Allogenic Dermal Matrix

Inclusion Criteria: Periodontally and systemically healthy adults Full-mouth plaque score and full-mouth bleeding score ≤ 20% Presence of at least one 3 mm or deeper gingival recession, with at least 1.5 mm of Keratinized tissue, and 1 mm of gingival thickness) requiring surgical intervention for root coverage No interproximal attachment/bone loss No prior experience of root coverage procedures within the last 1 year The patient must be able to perform good oral hygiene Exclusion Criteria: Contraindications for undergoing periodontal surgery Teeth with more than Grade II mobility, or furcation involvement of Class III Patients pregnant or attempting to get pregnant (self-reported), or nursing women Untreated/active periodontitis, or other untreated acute infections at the surgical site Untreated malignancies at the surgical site Persistence of uncorrected gingival trauma from traumatic toothbrushing Presence of severe tooth malposition, rotation or clinically significant super-eruption Self-reported current smoking more than 10 cigarettes/day or pipe or cigar smoking, or active tobacco chewing, or chronic vaping Patients with any known history of blood disorders or complications such as abnormal concentration of thrombin and factor XIII in plasma, or hemophilia Patients with significant co-morbidities, such as obesity, uncontrolled diabetes, immunosuppression, severe endocrine-induced bone diseases, signs of malnourishment, those receiving immunosuppressive therapy, poor tissue oxygenation or perfusion, and pre- or post-operative radiation Patients with known sensitivity to Polysorbate 20, Cefoxitin, Lincomycin, polymyxin B, Vancomycin