A Study of PER-001 in Participants With Open-Angle Glaucoma

Inclusion Criteria: For Phase 1 and Phase 2a: Must be ≥ 18 years of age at the time of signing the informed consent A negative pregnancy test for females of childbearing potential at Screening (serum) and Day 1 (urine). IOP 6 to 25 mmHg (inclusive) at Screening in potentially eligible eye(s) Phase 1: Best corrected visual acuity (BCVA) LogMAR score 1.0 or better at Screening in at least one eye and prior to randomization at Day 1 in the study eye Diagnosis of advanced or severe primary OAG including normal tension, pseudoexfoliation and pigment dispersion Phase 2: BCVA LogMAR score 0.5 or better at Screening in at least one eye and prior to randomization at Day 1 in the study eye Primary OAG that is progressing in the study eye Exclusion Criteria: Blood pressure >140/90 mmHg or <90/60 mmHg at Screening Any condition which, in the opinion of the investigator, would preclude the participant's ability to comply with study requirements including completion of the study (including but not limited to diagnosis of dementia, Alzheimer's, and/or other neurological disease or physical incapacity) Females who are pregnant, nursing, or planning a pregnancy during the study Any significant media opacity which precludes clinical evaluation and imaging of the retina History of vitrectomy surgery or retinal detachment or macular hole (Stage 3 or 4) Retinal laser within 3 months prior to Day 1 Intraocular surgery, including cataract surgery and Minimally Invasive Glaucoma Surgery (MIGS), within 3 months prior to Day 1 Aphakia or absence of posterior capsule Change in IOP lowering therapy within 6 weeks prior to Screening and/or anticipated change in IOP lowering therapy or treatment during the study Worse than mild non-proliferative diabetic retinopathy (Note: stable mild background diabetic retinopathy is permitted) Any active uveitis and/or vitritis or history of idiopathic or autoimmune-associated uveitis Active infectious conjunctivitis, keratitis, scleritis, or endophthalmitis (Note: mild blepharitis is permitted if stable) History of recurrent infectious or inflammatory ocular disease Central serous retinopathy Non-glaucomatous optic neuropathy