Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults
Cognitive Dysfunction, Mobility Limitation, Frail Elderly
About this trial
This is an interventional treatment trial for Cognitive Dysfunction
Eligibility Criteria
Inclusion Criteria: Age 65+ Objective executive function decline, based on standardized cognitive assessments. Subjective cognitive decline, based on the question: "During the past 12 months, have you experienced confusion or memory loss that is happening more often or getting worse?" Ability to walking independently for 6 minutes (use of cane permitted) Exclusion Criteria: Major cognitive disorder that interferes with independence Percentile score less than 10th percentile on standardized cognitive assessments Medications that are thought to influence tDCS neuroplasticity. Contraindications to tDCS or MRI.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Sham Comparator
Walking Exercise plus active tDCS
Walking Exercise plus sham tDCS
The walking exercise will focus on use of complex walking tasks such as obstacle crossing, accurate foot placement, and walking on compliant surfaces. Each session will consist of 30 minutes of walking. Active tDCS will be delivered over prefrontal cortex.
The walking exercise will focus on use of complex walking tasks such as obstacle crossing, accurate foot placement, and walking on compliant surfaces. Each session will consist of 30 minutes of walking. Sham tDCS will be delivered over prefrontal cortex.