GAIN Symptoms: Post-traumatic Headache
Post-Traumatic Headache, Concussion, Mild, MTBI - Mild Traumatic Brain Injury
About this trial
This is an interventional health services research trial for Post-Traumatic Headache focused on measuring Post-traumatic headache, Concussion, Mild Traumatic Brain Injury
Eligibility Criteria
Inclusion Criteria: mTBI within the last 2 to 4 months according to the diagnostic criteria recommended by the WHO task force age ≥ 18 years at the time of mTBI Rivermead Post-Concussion Symptoms Questionnaire (RPQ) score ≥ 3 (moderate or severe problem) for subitem headache and a diagnosis of persistent PTH attributed to mTBI according to ICHD-3. Additionally, for study 2 and 3, subjects have to be stable on preventative headache medication. However, subjects are permitted to take ''as needed'' (PRN) medications throughout the study with documentation in a daily headache diary. Exclusion Criteria: objective neurological findings and/or acute trauma CT scan indicating neurological disease or brain damage previous mTBI within the last 2 years years leading to PCS lasting ≥ 3 months. Additionally, for study 2 and 3, Pre-trauma headache frequency ≥ 10 days in average per month the last 3 months prior to mTBI. past history of TMS therapy or TMS-related contraindications (pacemaker, epilepsy etc.).
Sites / Locations
- Reseach Unit Hammel NeurocenterRecruiting
Arms of the Study
Arm 1
Arm 2
Sham Comparator
Active Comparator
Sham group
Active rTMS treatment
participants (n=50) will receive sham rTMS.
Participants (n=50) will receive active rTMS treatment.