Comparison of the detection rate per month of each individual condition, the infections and FGM cases, between the intervention and control centres
The monthly detection rate will be based on positive serologies, chest radiographies, ICD-9/ICD-10 of FGM and/or gynaecologist referrals, TST/IGRA and stool samples (for Andalusia), within the migrant patients who visited their assigned centre during the intervention period. Control and intervention PCCs will be compared before and after the implementation.
Comparison of the number of early HIV diagnoses
The number of early diagnoses of HIV will be assessed using the CD4 cell count of migrant patients diagnosed with an HIV infection. The early diagnoses will be compared between the control and intervention PCCs before and after the implementation. If possible, we will estimate the monthly detection rate of early diagnoses and also compare it between the intervention and control PCCs.
Comparison of the number of early HBV and HCV diagnoses
The number of early diagnoses of HBV and HCV will be assessed using the levels of transaminases, platelets, bilirubin, and clotting parameters from blood analyses of migrant patients diagnosed with HBV or HCV. The early diagnoses will be compared between the control and intervention PCCs before and after the implementation. If possible, we will estimate the monthly detection rate of early diagnoses and also compare it between the intervention and control PCCs.
Comparison of the number of screening tests performed for all aggregated infections
The number of the screening tests performed for all aggregated infections (serological tests, chest radiographies, TST or IGRA tests and stool samples in the case of the Andalusian site) will be compared between the intervention and control PCCs before and after the implementation.
Comparison of the the number of screening tests performed for each individual condition
The number of the screening tests performed for each individual condition will be compared between the intervention and control PCCs before and after the implementation.
Associations between the screening performance of all aggregated infections (yes/no) and patients' age (in years) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of the aggregated infections (yes-if the patient has been tested for at least one of the seven infections during the study period/no-if the patient was not tested) as the outcome variable and patients' age as the predictor variable.
Associations between the screening performance of all aggregated infections (yes/no) and the time that patients have been registered in the Spanish National Health System (in years) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of the aggregated infections (yes-if the patient has been tested for at least one of the seven infections during the study period/no-if the patient was not tested) as the outcome variable and time registered in the Spanish Health System as the predictor variable.
Associations between the screening performance of all aggregated infections (yes/no) and patients' sex (female/male) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of the aggregated infections (yes-if the patient has been tested for at least one of the seven infections during the study period/no-if the patient was not tested) as the outcome variable and patients' sex as the predictor variable.
Associations between the screening performance of all aggregated infections (yes/no) and patients' area of birth (Africa/Latin America/Asia/Eastern Europe) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of the aggregated infections (yes-if the patient has been tested for at least one of the seven infections during the study period/no-if the patient was not tested) as the outcome variable and patients' area of birth as the predictor variable. The areas of birth will be based in the geographical division of the United Nations Statistical Division.
Associations between the screening performance of all aggregated infections (yes/no) and the region where the PCC is located (Terres de l'Ebre/Lleida/Tarragona/Costa de Ponent) will be analysed using the data collected in the SISAP database
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of the aggregated infections (yes-if the patient has been tested for at least one of the seven infections during the study period/no-if the patient was not tested) as the outcome variable and the region of the PCC as the predictor variable.
Associations between the screening performance of all aggregated infections (yes/no) and the type of region where the PCC is located in Catalonia, Spain (urban/rural) will be analysed using the data collected in the SISAP database
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of the aggregated infections (yes-if the patient has been tested for at least one of the seven infections during the study period/no-if the patient was not tested) as the outcome variable and the type of region of the PCC as the predictor variable.
Associations between the screening performance of all aggregated infections (yes/no) and if the patient fulfilled the criteria of the screening recommendation (yes/no) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of the aggregated infections (yes-if the patient has been tested for at least one of the seven infections during the study period/no-if the patient was not tested) as the outcome variable and fulfilled the criteria of the screening recommendation (yes- if the patient had the criteria of being tested for at least one infection, criteria generated by the algorithm of the ISMiHealth software using the variables country of birth, age and sex/no- if the patient did not meet the criteria) as the predictor variable.
Associations between the screening performance of all aggregated infections (yes/no) and the arm of the study (Intervention/Control) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of the aggregated infections (yes-if the patient has been tested for at least one of the seven infections during the study period/no-if the patient was not tested) as the outcome variable and the arm of the study as the predictor variable.
Associations between the screening performance of all aggregated infections (yes/no) and patients' immunosuppression status (yes/no) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of the aggregated infections (yes-if the patient has been tested for at least one of the seven infections during the study period/no-if the patient was not tested) as the outcome variable and patients' immunosuppression status (yes- if the patient has an ICD-code diagnosis of an immunosuppressive disorder and/or have a prescription of an immunosuppressive drug/no- if the patient is not immunosuppressed) as the predictor variable.
Associations between the screening performance of all aggregated infections (yes/no) and the presence of another condition (yes/no) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of the aggregated infections (yes-if the patient has been tested for at least one of the seven infections during the study period/no-if the patient was not tested) as the outcome variable and the presence of another condition (yes- if the patient has an ICD-code of another condition [co-morbidity]/no- if the patient does not present another condition) as the predictor variable.
Associations between the screening performance of each individual condition (yes/no), including FGM, and patients' age (in years) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for one of the seven infections and/or screened for female genital mutilation/no-if the patient was not tested) as the outcome variable and patients' age as the predictor variable.
Associations between the screening performance of each individual condition (yes/no), including FGM, and the time that patients have been registered in the Spanish Health System (in years) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for one of the seven infections and/or screened for female genital mutilation/no-if the patient was not tested) as the outcome variable and time registered in the Spanish Health System as the predictor variable.
Associations between the screening performance of each individual condition (yes/no), including FGM, and patients' sex (female/male) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes- yes-if the patient has been tested for one of the seven infections and/or screened for female genital mutilation/no-if the patient was not tested) as the outcome variable and patients' sex as the predictor variable.
Associations between the screening performance of each individual condition (yes/no), including FGM, and patients' area of birth (Africa/Latin America/Asia/Eastern Europe) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for one of the seven infections and/or screened for female genital mutilation/no-if the patient was not tested) as the outcome variable and patients' area of birth as the predictor variable. The areas of birth will be based in the geographical division of the United Nations Statistical Division.
Associations between the screening performance of each individual condition (yes/no), including FGM, and the region where the PCC is located (Terres de l'Ebre/Lleida/Tarragona/Costa de Ponent) will be analysed using data collected in the SISAP database
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for one of the seven infections and/or screened for female genital mutilation/no-if the patient was not tested) as the outcome variable and the region of the PCC as the predictor variable.
Associations between the screening performance of each individual condition (yes/no), including FGM, and the type of region where the PCC is located in Catalonia, Spain (urban/rural) will be analysed using the data collected in the SISAP database
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for one of the seven infections and/or screened for female genital mutilation/no-if the patient was not tested) as the outcome variable and the type of region of the PCC as the predictor variable.
Associations between the screening performance each individual condition (yes/no), including FGM, and if the patient fulfilled the criteria of the screening recommendation (yes/no) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for one of the seven infections and/or screened for female genital mutilation/no-if the patient was not tested) as the outcome variable and fulfilled the criteria of the screening recommendation (yes- if the patient had the criteria of being tested for at least one infection, criteria generated by the algorithm of the ISMiHealth software using the variables country of birth, age and sex/no- if the patient did not meet the criteria) as the predictor variable.
Associations between the screening performance of each individual condition (yes/no), including FGM, and the arm of the study (Intervention/Control) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for one of the seven infections and/or screened for female genital mutilation/no-if the patient was not tested) as the outcome variable and the arm of the study as the predictor variable.
Associations between the screening performance of each individual condition (yes/no), including FGM, and patients' immunosuppression status (yes/no) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for one of the seven infections and/or screened for female genital mutilation/no-if the patient was not tested) as the outcome variable and patients' immunosuppression status (yes- if the patient has an ICD-code diagnosis of an immunosuppressive disorder and/or have a prescription of an immunosuppressive drug/no- if the patient is not immunosuppressed) as the predictor variable.
Associations between the screening performance of each individual condition (yes/no), including FGM, and the presence of another condition (yes/no) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for one of the seven infections and/or screened for female genital mutilation/no-if the patient was not tested) as the outcome variable and the presence of another condition (yes- if the patient has an ICD-code of another condition [co-morbidity]/no- if the patient does not present another condition) as the predictor variable.
Associations between the screening performance of HIV (yes/no) and the CD4 cell count (cell/µL) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for HIV during the study period/no-if the patient was not tested) as the outcome variable and the CD4 cell count as the predictor variable.
Associations between the screening performance of HIV (yes/no) and the viral load (copies/mL) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for HIV /no-if the patient was not tested) as the outcome variable and the viral load as the predictor variable.
Associations between the screening performance of HBV and/or HCV (yes/no) and the levels of platelets (U/µL) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for HBV and/or HCV /no-if the patient was not tested) as the outcome variable and the levels of platelets as the predictor variable.
Associations between the screening performance of HBV and/or HCV (yes/no) and the levels of transaminases (U/L) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for HBV and/or HCV /no-if the patient was not tested) as the outcome variable and the levels of transaminases as the predictor variable.
Associations between the screening performance of HBV and/or HCV (yes/no) and the levels of bilirubin (mg/dL) will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for HBV and/or HCV /no-if the patient was not tested) as the outcome variable and the levels of bilirubin as the predictor variable.
Associations between the screening performance of HBV and/or HCV (yes/no) and the levels of clotting parameters [such as prothrombin (seconds), fibrinogen (mg/dL), among others] will be analysed using the data collected from the EPR system
Bivariate and multivariate analysis (Fisher's exact tests, Chi-square tests and/or logistic regressions) will be performed using the screening performance of each individual condition (yes-if the patient has been tested for HBV and/or HCV /no-if the patient was not tested) as the outcome variable and the levels of clotting parameters as the predictor variable.
Number of diagnosed individuals with follow-up visits in the hospital of reference
The number of migrant patients under follow-up in the hospital after a diagnosis of an infection or FGM will be estimated using the Minimum basic dataset (MBDS).
Number of diagnosed individuals under treatment
The number of migrant patients under treatment after a diagnosis will be estimated using data from the EPR systems and the MBDS.