A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-1)
Obesity, Overweight, Overweight or Obesity
About this trial
This is an interventional treatment trial for Obesity
Eligibility Criteria
Inclusion Criteria: Have a BMI ≥30.0 kilogram/square meter (kg/m²), ≥27.0 kg/m² and presence of at least 1 of the following weight-related comorbidities (treated or untreated) at screening: Hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease (for example, ischemic cardiovascular disease, New York Heart Association Functional Class I-III heart failure). Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight. Exclusion Criteria: Have Type 1 diabetes, Type 2 diabetes, or any other types of diabetes, history of ketoacidosis, or hyperosmolar state/coma Have a self-reported change in body weight >5 kg (11 pounds) within 90 days prior to screening. Have family (first-degree relative) or personal history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia (MEN)2 syndrome. Have had a history of chronic or acute pancreatitis.
Sites / Locations
- The Institute for Liver Health dba Arizona Clinical TrialsRecruiting
- Clinical Research Institute of Arizona (CRI) - Sun City WestRecruiting
- John Muir Physician Network Research CenterRecruiting
- AMCR InstituteRecruiting
- NorCal Medical Research, IncRecruiting
- National Research Institute - Huntington ParkRecruiting
- National Research Institute - WilshireRecruiting
- Catalina Research Institute, LLCRecruiting
- Norcal Endocrinology & Internal MedicineRecruiting
- University Clinical Investigators, Inc.Recruiting
- University of Colorado Anschutz Medical CampusRecruiting
- East Coast Institute for Research, LLCRecruiting
- New Age Medical Research CorporationRecruiting
- Renstar Medical ResearchRecruiting
- South Broward ResearchRecruiting
- Jedidiah Clinical Research - Tampa - Bay PlazaRecruiting
- Clinical Site Partners, LLC dba Flourish ResearchRecruiting
- Physicians Research AssociatesRecruiting
- Rophe Adult and Pediatric Medicine/SKYCRNGRecruiting
- East-West Medical Research InstituteRecruiting
- Elite Clinical TrialsRecruiting
- Cotton O'Neil Clinical Research Center - Central OfficeRecruiting
- Cotton O'Neil Clinical Research CenterRecruiting
- Pennington Biomedical Research CenterRecruiting
- Care Access - Lake CharlesRecruiting
- MedStar Health Research Institute (MedStar Physician Based Research Network)Recruiting
- Endocrine and Metabolic ConsultantsRecruiting
- Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionRecruiting
- SKY Integrative Medical Center/SKYCRNGRecruiting
- Las Vegas Medical ResearchRecruiting
- Long Island Cardiovascular ConsultantsRecruiting
- Alliance for Multispecialty Research, LLCRecruiting
- Texas Diabetes & Endocrinology, P.A.Recruiting
- Thyroid, Endocrinology, and DiabetesRecruiting
- Dallas Diabetes Research CenterRecruiting
- Cedar Health ResearchRecruiting
- Juno ResearchRecruiting
- Consano Clinical Research, LLCRecruiting
- Soma Clinical TrialsRecruiting
- Physicians' Research OptionsRecruiting
- Health Research of Hampton Roads, Inc.Recruiting
- Eastside Research AssociatesRecruiting
- Private Practice - Dr.Miguel N. HissaRecruiting
- CEDOESRecruiting
- Hospital São DomingosRecruiting
- Pesquisa Clínica em Diabetes - Dra Rosângela RéaRecruiting
- Núcleo de Pesquisa Clínica do Rio Grande do SulRecruiting
- Centro de Pesquisa Sao LucasRecruiting
- CECIP - Centro de Estudos do Interior PaulistaRecruiting
- Centro Multidisciplinar de Estudos ClinicosRecruiting
- Integral Pesquisa e EnsinoRecruiting
- Hospital São Lucas de CopacabanaRecruiting
- CPQuali Pesquisa ClínicaRecruiting
- Hospital das Clinicas FMUSPRecruiting
- Chinese PLA General HospitalRecruiting
- Chongqing General HospitalRecruiting
- ShenZhen People's Hospital
- Hainan General HospitalRecruiting
- The First Affiliated Hospital of Henan University of Science &TechnologyRecruiting
- The Second Affiliated Hospital of Zhengzhou UniversityRecruiting
- Nanjing First HospitalRecruiting
- The Second Affiliated Hospital of Nanjing Medical UniversityRecruiting
- The First Affiliated Hospital of Soochow UniversityRecruiting
- Jinan Central HospitalRecruiting
- Tianjin Medical University General HospitalRecruiting
- Tianjin Medical University Zhu Xianyi Memorial HospitalRecruiting
- The First People's Hospital of Yunnan ProvinceRecruiting
- Zhejiang HospitalRecruiting
- Ningbo First HospitalRecruiting
- Endolife Speciality Hospitals
- Lady Hardinge Medical College
- Victoria Hospital, Bangalore Medical College And Research Institute
- Government Medical College And Hospital - Nagpur
- All India Institute of Medical Sciences (AIIMS) - Nagpur
- Deenanath Mangeshkar Hospital & Research Centre
- Sahyadri Super Speciality Hospital
- Lifepoint Multispeciality Hospital
- Oishi ClinicRecruiting
- Mazda HospitalRecruiting
- Tsuchiura Medical & Health Care CenterRecruiting
- NTT Nishinihon Takamatsu ClinicRecruiting
- Iwamoto Internal Medicine ClinicRecruiting
- Yokohama Minoru ClinicRecruiting
- Medical Corporation Heishinkai OCROM ClinicRecruiting
- Sugiura Internal Medicine ClinicRecruiting
- Adachi Kyosai HospitalRecruiting
- Tokyo-Eki Center-building ClinicRecruiting
- Medical Corporation Chiseikai Tokyo Center ClinicRecruiting
- Fukuwa ClinicRecruiting
- Yutenji Medical ClinicRecruiting
- Kanno NaikaRecruiting
- Shimokitazawa Tomo ClinicRecruiting
- Heishinkai Medical Group ToCROM ClinicRecruiting
- Boocs Clinic FukuokaRecruiting
- AMC Nishiumeda ClinicRecruiting
- Gachon University Gil Medical CenterRecruiting
- Korea University Ansan Hospital
- Hallym University Sacred Heart HospitalRecruiting
- Ajou University HospitalRecruiting
- Pusan National University Yangsan HospitalRecruiting
- Seoul National University HospitalRecruiting
- Konyang University HospitalRecruiting
- Dorado Medical ComplexRecruiting
- GCM Medical Group, PSC - Hato Rey SiteRecruiting
- Nemocnica s poliklinikou LucenecRecruiting
- Metabol KLINIKRecruiting
- Human Care s.r.o.Recruiting
- Areteus s.r.o.Recruiting
- DIAB sroRecruiting
- MEDI-DIA s.r.o.Recruiting
- Diacrin .s.ro.Recruiting
- MediTaskRecruiting
- CHUAC-Complejo Hospitalario Universitario A CoruñaRecruiting
- Centro Periférico de Especialidades Bola AzulRecruiting
- Hospital Universitario Virgen de la VictoriaRecruiting
- Hospital Quiron Infanta LuisaRecruiting
- Hospital Germans Trias i PujolRecruiting
- Hospital Universitari Vall d'HebronRecruiting
- Hospital Virgen del CaminoRecruiting
- Hospital Virgen de las MontañasRecruiting
- Hospital General Universitario de ValenciaRecruiting
- Hospital Universitari i Politecnic La FeRecruiting
- Changhua Christian HospitalRecruiting
- Chiayi Christian HospitalRecruiting
- Chang Gung Memorial Hospital at KaohsiungRecruiting
- Kaohsiung Medical University Chung-Ho Memorial HospitalRecruiting
- National Cheng Kung University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Placebo Comparator
Orforglipron Dose 1
Orforglipron Dose 2
Orforglipron Dose 3
Placebo
Participant will receive orforglipron administered orally.
Participant will receive orforglipron administered orally.
Participant will receive orforglipron administered orally.
Participants will be given placebo.