A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-1)
Obesity, Overweight, Overweight or Obesity

About this trial
This is an interventional treatment trial for Obesity
Eligibility Criteria
Inclusion Criteria: Have a BMI ≥30.0 kilogram/square meter (kg/m²), ≥27.0 kg/m² and presence of at least 1 of the following weight-related comorbidities (treated or untreated) at screening: Hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease (for example, ischemic cardiovascular disease, New York Heart Association Functional Class I-III heart failure). Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight. Exclusion Criteria: Have Type 1 diabetes, Type 2 diabetes, or any other types of diabetes, history of ketoacidosis, or hyperosmolar state/coma Have a self-reported change in body weight >5 kg (11 pounds) within 90 days prior to screening. Have family (first-degree relative) or personal history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia (MEN)2 syndrome. Have had a history of chronic or acute pancreatitis.
Sites / Locations
- The Institute for Liver Health dba Arizona Clinical TrialsRecruiting
 - Clinical Research Institute of Arizona (CRI) - Sun City WestRecruiting
 - John Muir Physician Network Research CenterRecruiting
 - AMCR InstituteRecruiting
 - NorCal Medical Research, IncRecruiting
 - National Research Institute - Huntington ParkRecruiting
 - National Research Institute - WilshireRecruiting
 - Catalina Research Institute, LLCRecruiting
 - Norcal Endocrinology & Internal MedicineRecruiting
 - University Clinical Investigators, Inc.Recruiting
 - University of Colorado Anschutz Medical CampusRecruiting
 - East Coast Institute for Research, LLCRecruiting
 - New Age Medical Research CorporationRecruiting
 - Renstar Medical ResearchRecruiting
 - South Broward ResearchRecruiting
 - Jedidiah Clinical Research - Tampa - Bay PlazaRecruiting
 - Clinical Site Partners, LLC dba Flourish ResearchRecruiting
 - Physicians Research AssociatesRecruiting
 - Rophe Adult and Pediatric Medicine/SKYCRNGRecruiting
 - East-West Medical Research InstituteRecruiting
 - Elite Clinical TrialsRecruiting
 - Cotton O'Neil Clinical Research Center - Central OfficeRecruiting
 - Cotton O'Neil Clinical Research CenterRecruiting
 - Pennington Biomedical Research CenterRecruiting
 - Care Access - Lake CharlesRecruiting
 - MedStar Health Research Institute (MedStar Physician Based Research Network)Recruiting
 - Endocrine and Metabolic ConsultantsRecruiting
 - Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionRecruiting
 - SKY Integrative Medical Center/SKYCRNGRecruiting
 - Las Vegas Medical ResearchRecruiting
 - Long Island Cardiovascular ConsultantsRecruiting
 - Alliance for Multispecialty Research, LLCRecruiting
 - Texas Diabetes & Endocrinology, P.A.Recruiting
 - Thyroid, Endocrinology, and DiabetesRecruiting
 - Dallas Diabetes Research CenterRecruiting
 - Cedar Health ResearchRecruiting
 - Juno ResearchRecruiting
 - Consano Clinical Research, LLCRecruiting
 - Soma Clinical TrialsRecruiting
 - Physicians' Research OptionsRecruiting
 - Health Research of Hampton Roads, Inc.Recruiting
 - Eastside Research AssociatesRecruiting
 - Private Practice - Dr.Miguel N. HissaRecruiting
 - CEDOESRecruiting
 - Hospital São DomingosRecruiting
 - Pesquisa Clínica em Diabetes - Dra Rosângela RéaRecruiting
 - Núcleo de Pesquisa Clínica do Rio Grande do SulRecruiting
 - Centro de Pesquisa Sao LucasRecruiting
 - CECIP - Centro de Estudos do Interior PaulistaRecruiting
 - Centro Multidisciplinar de Estudos ClinicosRecruiting
 - Integral Pesquisa e EnsinoRecruiting
 - Hospital São Lucas de CopacabanaRecruiting
 - CPQuali Pesquisa ClínicaRecruiting
 - Hospital das Clinicas FMUSPRecruiting
 - Chinese PLA General HospitalRecruiting
 - Chongqing General HospitalRecruiting
 - ShenZhen People's Hospital
 - Hainan General HospitalRecruiting
 - The First Affiliated Hospital of Henan University of Science &TechnologyRecruiting
 - The Second Affiliated Hospital of Zhengzhou UniversityRecruiting
 - Nanjing First HospitalRecruiting
 - The Second Affiliated Hospital of Nanjing Medical UniversityRecruiting
 - The First Affiliated Hospital of Soochow UniversityRecruiting
 - Jinan Central HospitalRecruiting
 - Tianjin Medical University General HospitalRecruiting
 - Tianjin Medical University Zhu Xianyi Memorial HospitalRecruiting
 - The First People's Hospital of Yunnan ProvinceRecruiting
 - Zhejiang HospitalRecruiting
 - Ningbo First HospitalRecruiting
 - Endolife Speciality Hospitals
 - Lady Hardinge Medical College
 - Victoria Hospital, Bangalore Medical College And Research Institute
 - Government Medical College And Hospital - Nagpur
 - All India Institute of Medical Sciences (AIIMS) - Nagpur
 - Deenanath Mangeshkar Hospital & Research Centre
 - Sahyadri Super Speciality Hospital
 - Lifepoint Multispeciality Hospital
 - Oishi ClinicRecruiting
 - Mazda HospitalRecruiting
 - Tsuchiura Medical & Health Care CenterRecruiting
 - NTT Nishinihon Takamatsu ClinicRecruiting
 - Iwamoto Internal Medicine ClinicRecruiting
 - Yokohama Minoru ClinicRecruiting
 - Medical Corporation Heishinkai OCROM ClinicRecruiting
 - Sugiura Internal Medicine ClinicRecruiting
 - Adachi Kyosai HospitalRecruiting
 - Tokyo-Eki Center-building ClinicRecruiting
 - Medical Corporation Chiseikai Tokyo Center ClinicRecruiting
 - Fukuwa ClinicRecruiting
 - Yutenji Medical ClinicRecruiting
 - Kanno NaikaRecruiting
 - Shimokitazawa Tomo ClinicRecruiting
 - Heishinkai Medical Group ToCROM ClinicRecruiting
 - Boocs Clinic FukuokaRecruiting
 - AMC Nishiumeda ClinicRecruiting
 - Gachon University Gil Medical CenterRecruiting
 - Korea University Ansan Hospital
 - Hallym University Sacred Heart HospitalRecruiting
 - Ajou University HospitalRecruiting
 - Pusan National University Yangsan HospitalRecruiting
 - Seoul National University HospitalRecruiting
 - Konyang University HospitalRecruiting
 - Dorado Medical ComplexRecruiting
 - GCM Medical Group, PSC - Hato Rey SiteRecruiting
 - Nemocnica s poliklinikou LucenecRecruiting
 - Metabol KLINIKRecruiting
 - Human Care s.r.o.Recruiting
 - Areteus s.r.o.Recruiting
 - DIAB sroRecruiting
 - MEDI-DIA s.r.o.Recruiting
 - Diacrin .s.ro.Recruiting
 - MediTaskRecruiting
 - CHUAC-Complejo Hospitalario Universitario A CoruñaRecruiting
 - Centro Periférico de Especialidades Bola AzulRecruiting
 - Hospital Universitario Virgen de la VictoriaRecruiting
 - Hospital Quiron Infanta LuisaRecruiting
 - Hospital Germans Trias i PujolRecruiting
 - Hospital Universitari Vall d'HebronRecruiting
 - Hospital Virgen del CaminoRecruiting
 - Hospital Virgen de las MontañasRecruiting
 - Hospital General Universitario de ValenciaRecruiting
 - Hospital Universitari i Politecnic La FeRecruiting
 - Changhua Christian HospitalRecruiting
 - Chiayi Christian HospitalRecruiting
 - Chang Gung Memorial Hospital at KaohsiungRecruiting
 - Kaohsiung Medical University Chung-Ho Memorial HospitalRecruiting
 - National Cheng Kung University HospitalRecruiting
 
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Placebo Comparator
Orforglipron Dose 1
Orforglipron Dose 2
Orforglipron Dose 3
Placebo
Participant will receive orforglipron administered orally.
Participant will receive orforglipron administered orally.
Participant will receive orforglipron administered orally.
Participants will be given placebo.