Combining VNS With PT Interventions for Individuals With PD (VNS-PT-PD)
Parkinson Disease
About this trial
This is an interventional treatment trial for Parkinson Disease focused on measuring Parkinson's Disease, Exercise, Vagus Nerve Stimulation, VNS, taVNS
Eligibility Criteria
Inclusion Criteria: age between 35 and 80 years no walking aids stable medication 4 weeks prior to and during the study no falls in the past 6 months participant must have MD who is willing to provide oversight and approval for clinically defined "off" state Exclusion Criteria: mild cognitive impairment (MoCA <25) self reported depression antidepressive or antipsychotic medication participation in a VNS study in the past year disabling bradykinesia to ensure patients are able to participate in intensive physiotherapy (based on clinical impression and in accordance to UPDRS part III item 14 - to be administered in clinic) prior history of cardiovascular, neurological or musculoskeletal disorders known to interfere with testing PD features implanted medical device of any type history of seizures peripheral neuropathy including temporal mandibular disorders and Bells Palsy, and vasovagal syncope.
Sites / Locations
- WHARFRecruiting
- UABRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
active taVNS + exercise
sham taVNS + exercise
Participants who are randomized into the active taVNS + exercise group will receive 15 minutes of active taVNS prior to exercise sessions.
Participants who are randomized into the sham taVNS + exercise group will receive 0 mA of current for 15 minutes prior to exercise sessions.