A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes (ATTAIN-2)
Obesity, Overweight, Type 2 Diabetes
About this trial
This is an interventional treatment trial for Obesity
Eligibility Criteria
Inclusion Criteria: Have a body mass index (BMI) ≥27.0 kilogram/square meter (kg/m²). Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight. Have a diagnosis of Type 2 Diabetes (T2D), with HbA1c ≥7% (≥53 mmol/mol) to ≤10% (86 mmol/mol) and are on stable treatment for T2D for at least 90 days prior to screening, consisting of: either diet/exercise alone or up to 3 oral antihyperglycemic medications (excluding dipeptidyl peptidase IV inhibitors (DPP-4i) or glucagon-like peptide-1 (GLP-1) receptor agonists (RA). Exclusion Criteria: Have Type 1 Diabetes (T1D), history of ketoacidosis or hyperosmolar state/coma, or any other types of diabetes except T2D. Have a self-reported change in body weight >5 kg (11 pounds) within 90 days prior to screening. Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema (for example, laster photocoagulation or intravitreal injections of anti-vascular endothelial growth factor inhibitors). Have family (first-degree relative) or personal history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia 2 (MEN2) syndrome. Have had a history of chronic or acute pancreatitis.
Sites / Locations
- Cahaba Research - PelhamRecruiting
- Novak Clinical Research - Tucson - North La Cholla BoulevardRecruiting
- Yuma Clinical TrialsRecruiting
- AMCR InstituteRecruiting
- National Research Institute - Huntington ParkRecruiting
- National Research Institute - WilshireRecruiting
- Catalina Research Institute, LLCRecruiting
- University Clinical Investigators, Inc.Recruiting
- Encore Medical ResearchRecruiting
- East Coast Institute for Research, LLCRecruiting
- South Florida Clinical Research InstituteRecruiting
- Suncoast Clinical Research, Inc.Recruiting
- Balanced Life Health Care Solutions/SKYCRNGRecruiting
- Endocrine Research Solutions, Inc.Recruiting
- North Georgia Clinical ResearchRecruiting
- Pacific Diabetes & Endocrine CenterRecruiting
- Solaris Clinical ResearchRecruiting
- Iowa Diabetes and Endocrinology Research CenterRecruiting
- Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionRecruiting
- StudyMetrix ResearchRecruiting
- Las Vegas Medical ResearchRecruiting
- Albuquerque Neuroscience Inc.Recruiting
- Albany Medical College, Division of Community EndocrinologyRecruiting
- Albany Stratton VA Medical CenterRecruiting
- NYC Research INCRecruiting
- Accellacare - RaleighRecruiting
- Summit HeadlandsRecruiting
- Alliance for Multispecialty Research, LLCRecruiting
- Dallas Diabetes Research CenterRecruiting
- Soma Clinical TrialsRecruiting
- Epic Medical Research - DeSotoRecruiting
- Biopharma Informatic, LLCRecruiting
- Diabetes and Glandular Disease CenterRecruiting
- VIP TrialsRecruiting
- Charlottesville Medical ResearchRecruiting
- Universal Research GroupRecruiting
- CEMEDIABRecruiting
- Mautalen Salud e InvestigaciónRecruiting
- Instituto CentenarioRecruiting
- Instituto de Investigaciones Clinicas RosarioRecruiting
- Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención MedicaRecruiting
- Sanatorio San MartinRecruiting
- Centro de Investigaciones Médicas TucumanRecruiting
- CONEXA Investigacion Clinica S.A.Recruiting
- Centro Diabetológico Dr. WaitmanRecruiting
- Centro de Diagnóstico y Rehabilitación (CEDIR)Recruiting
- Optimus Clinical ResearchRecruiting
- The AIM Centre / Hunter Diabetes CentreRecruiting
- Royal Brisbane and Women's HospitalRecruiting
- Core Research GroupRecruiting
- Logan HospitalRecruiting
- Southern Adelaide Diabetes & Endocrine ServicesRecruiting
- Box Hill HospitalRecruiting
- Emeritus ResearchRecruiting
- Austin Health - Repatriation HospitalRecruiting
- Baker IDI Heart and Diabetes Institute - MelbourneRecruiting
- GenesisCareRecruiting
- Centro de Pesquisa Clinica do BrasilRecruiting
- Cendi - Endocrinologia e DiabetesRecruiting
- Instituto LóbusRecruiting
- Instituto Méderi de Pesquisa e SaúdeRecruiting
- Instituto de Pesquisa clinica de CampinasRecruiting
- Centro de Pesquisa Clínica de Marília - CPCLIMRecruiting
- Pesquisare SaudeRecruiting
- Hospital das Clinicas FMUSPRecruiting
- The Second People's Hospital of HefeiRecruiting
- Chinese PLA General HospitalRecruiting
- Chongqing General HospitalRecruiting
- ShenZhen People's Hospital
- Hainan General Hospital
- The First Affiliated Hospital of Henan University of Science &TechnologyRecruiting
- The Second Affiliated Hospital of Zhengzhou University
- Nanjing First HospitalRecruiting
- The Second Affiliated Hospital of Nanjing Medical UniversityRecruiting
- Nantong First People's HospitalRecruiting
- Dalian Municipal Central Hospital Affiliated of Dalian Medical University
- Jinan Central HospitalRecruiting
- Tianjin Medical University General Hospital
- Tianjin Medical University Zhu Xianyi Memorial Hospital
- The First People's Hospital of Yunnan ProvinceRecruiting
- MUDr. Alena VachovaRecruiting
- MUDr. Tomas EdelsbergerRecruiting
- Diahelp s.r.oRecruiting
- Dialine - Interni a diabetologicka ambulanceRecruiting
- Diabet2 s.r.o., diabetologicka a interni ambulanceRecruiting
- Milan Kvapil s.r.o., Diabetologicka ambulanceRecruiting
- ResTrial s.r.o.Recruiting
- MUDr. Sabina PalovaRecruiting
- Milan Kvapil s.r.o., Diabetologicka ambulance PribramRecruiting
- Endokrinologie MUDr. Rehorkova s.r.o.Recruiting
- MUDr. Jitka Zemanová - diabetologie a interna s.r.o.Recruiting
- CDG Studienambulanz HartardRecruiting
- Gemeinschaftspraxis Dr. med. Josef und Wilma GroßkopfRecruiting
- Diabetologische Schwerpunktpraxis Marck Linn PickelRecruiting
- InnoDiab Forschung GmbhRecruiting
- Medizentrum Essen BorbeckRecruiting
- University Hospital of CologneRecruiting
- Institut für Diabetesforschung GmbH MünsterRecruiting
- Practice Dr.med. Denger and Dr.med. PfitznerRecruiting
- Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - WeiβenfelsRecruiting
- SMO.MD GmbHRecruiting
- AmBeNet GmbHRecruiting
- Private Practice - Dr. Christine KoschRecruiting
- RED-Institut GmbHRecruiting
- Diabetes Zentrum Dr. TewsRecruiting
- Diabetes Zentrum WilhelmsburgRecruiting
- Universität zu Lübeck - Institut für Endokrinologie und DiabetesRecruiting
- Athens Medical CenterRecruiting
- Euromedica General Clinic of ThessalonikiRecruiting
- Papageorgiou General Hospital of ThessalonikiRecruiting
- Thermi ClinicRecruiting
- University General Hospital of Larissa
- Dr B. L. Kapur Memorial Hospital
- Shree Krishna Hospital
- Medstar Speciality HospitalRecruiting
- TOTALL Diabetes Hormone Institute
- Topiwala National Medical College & B. Y. L. Nair Charitable Hospital
- BSES MG Hospital
- All India Institute of Medical Sciences (AIIMS) - Nagpur
- Sahyadri Super Speciality Hospital
- Arthur Asirvatham HospitalRecruiting
- Kumudini Devi Diabetes Research Center
- Yonsei University-Wonju Severance Christian HospitalRecruiting
- Seoul National University Bundang HospitalRecruiting
- Yeungnam Univeristy Medical CenterRecruiting
- Korea University Anam HospitalRecruiting
- Kyung Hee University Hospital at GangdongRecruiting
- The Catholic Univ. of Korea Seoul St. Mary's HospitalRecruiting
- Advanced Clinical Research, LLCRecruiting
- Private Practice - Dr. Paola Mansilla-LetelierRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Placebo Comparator
Orforglipron Dose 1
Orforglipron Dose 2
Orforglipron Dose 3
Placebo
Participants will receive orforglipron administered orally.
Participants will receive orforglipron administered orally.
Participants will receive orforglipron administered orally.
Participants will receive placebo