A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease (TRIUMPH-3)
Obesity, Cardiovascular Diseases
About this trial
This is an interventional treatment trial for Obesity
Eligibility Criteria
Inclusion Criteria: Have a body mass index (BMI) ≥35.0 kilogram/square meter (kg/m²). Have established cardiovascular (CV) disease with at least 1 of the following: prior myocardial infarction prior ischemic or hemorrhagic stroke, or symptomatic peripheral arterial disease Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight. Exclusion Criteria: Have had acute myocardial infarction, stroke, coronary revascularization, hospitalization for unstable angina, or hospitalization due to congestive heart failure within 90 days prior to screening. Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening. Have a prior or planned surgical treatment of obesity. Have a change in body weight greater than 5 kg (11 pounds) within 90 days prior to screening. Have Type 1 diabetes. Have family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2) Have had pancreatitis.
Sites / Locations
- Central Phoenix Medical ClinicRecruiting
- Valley Clinical Trials, Inc.Recruiting
- Valley ResearchRecruiting
- Collaborative Neuroscience Research, LLCRecruiting
- National Research Institute - WilshireRecruiting
- Valley Clinical Trials, Inc.Recruiting
- Velocity Clinical Research, Panorama CityRecruiting
- Chase Medical Research, LLCRecruiting
- Clinical Neuroscience Solutions, Inc. dba CNS HealthcareRecruiting
- Clinical Neuroscience SolutionsRecruiting
- Progressive Medical ResearchRecruiting
- Charter Research - Winter ParkRecruiting
- Pacific Diabetes & Endocrine CenterRecruiting
- Humphreys Diabetes CenterRecruiting
- Northwestern UniversityRecruiting
- Great Lakes Clinical Trials - GurneeRecruiting
- Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research CooperativeRecruiting
- Brengle Family MedicineRecruiting
- Iowa Diabetes and Endocrinology Research CenterRecruiting
- Cotton O'Neil Clinical Research CenterRecruiting
- MedVadis Research CorporationRecruiting
- StudyMetrix ResearchRecruiting
- Las Vegas Medical ResearchRecruiting
- Palm Research Center TenayaRecruiting
- Amici Clinical Research LLCRecruiting
- Rochester Clinical Research, Inc.Recruiting
- Carteret Medical GroupRecruiting
- Altoona Center For Clinical ResearchRecruiting
- Tribe Clinical Research, LLCRecruiting
- Trial Management AssociatesRecruiting
- Tribe Clinical Research - SpartanburgRecruiting
- Texas Diabetes & Endocrinology, P.A.Recruiting
- Pinnacle Clinical ResearchRecruiting
- Southern Endocrinology AssociatesRecruiting
- Sleep Therapy Research CenterRecruiting
- Consano Clinical Research, LLCRecruiting
- Advanced Research InstituteRecruiting
- Rainier Clinical Research CenterRecruiting
- CEDICRecruiting
- Centro de Investigaciones Metabólicas (CINME)Recruiting
- IDIM - Instituto de Diagnóstico e Investigaciones MetabólicasRecruiting
- MICA - Medicina e Investigación CardiometabólicaRecruiting
- Instituto de Investigaciones Clínicas Mar del PlataRecruiting
- DIM Clínica PrivadaRecruiting
- Instituto de Investigaciones Clinicas Zarate
- Stat Research S.A.Recruiting
- Centro Médico ViamonteRecruiting
- Investigaciones Medicas Imoba SrlRecruiting
- Consultorio de Investigación Clínica EMO SRLRecruiting
- Centro Medico Dra. Laura Maffei- Investigacion Clinica AplicadaRecruiting
- Centro Medico Privado CEMAICRecruiting
- Centro Medico Privado San Vicente DiabetesRecruiting
- Centro de Salud e Investigaciones MédicasRecruiting
- CIPADI - Centro Integral de Prevencion y Atencion en DiabetesRecruiting
- Centro de Investigaciones Clínicas BaigorriaRecruiting
- Instituto de Investigaciones Clinicas RosarioRecruiting
- Instituto de Investigaciones Clinicas ZarateRecruiting
- Sanatorio San MartinRecruiting
- Sanatorio NorteRecruiting
- Centro de Investigaciones Médicas TucumanRecruiting
- Fundación RespirarRecruiting
- Instituto Médico DAMICRecruiting
- Centro de Investigaciones Clinicas del LitoralRecruiting
- Canberra HospitalRecruiting
- Optimus Clinical ResearchRecruiting
- The AIM Centre / Hunter Diabetes CentreRecruiting
- University of Sydney - Charles Perkins CentreRecruiting
- Royal Brisbane and Women's HospitalRecruiting
- Core Research GroupRecruiting
- Coastal Digestive HealthRecruiting
- Logan HospitalRecruiting
- Fusion Clinical ResearchRecruiting
- Nightingale ResearchRecruiting
- Southern Adelaide Diabetes & Endocrine ServicesRecruiting
- Box Hill HospitalRecruiting
- Emeritus ResearchRecruiting
- Barwon HealthRecruiting
- Austin Health - Repatriation HospitalRecruiting
- One Clinical Research
- BC Diabetes OfficeRecruiting
- Discovery Clinical ServicesRecruiting
- True North Clinical Research
- Joanne F. Liutkus Medicine Professional CorporationRecruiting
- LMC Clinical Research Inc. (Thornhill)Recruiting
- Dr. Steven V. Zizzo Medicine Professional CorporationRecruiting
- Milestone Research Inc.Recruiting
- North York Diagnostic and Cardiac Centre
- Centricity Research OshawaRecruiting
- Kawartha Cardiology Clinical TrialsRecruiting
- Manna Research TorontoRecruiting
- Ecogene-21 - CmasRecruiting
- Ecogene-21Recruiting
- Clinique de médecine Urbaine du Quartier LatinRecruiting
- CardioVasc HR Inc
- Centre de Medecine Metabolique de Lanaudiere (CMML)Recruiting
- Syneos HealthRecruiting
- Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai KözpontRecruiting
- Regia Med KftRecruiting
- Medifarma 98 KftRecruiting
- Óbudai Egészségügyi Centrum - Kaposvár SiteRecruiting
- DRC Gyógyszervizsgáló KözpontRecruiting
- Zala Megyei Szent Rafael Kórház
- Óbudai Egészségügyi CentrumRecruiting
- ClinDiab Kft.Recruiting
- TRANTOR'99 Bt. Anyagcsere CentrumRecruiting
- Óbudai Egészségügyi Centrum - ZalaegerszegRecruiting
- Centro de Investigacion Cardiovascular y MetabólicaRecruiting
- RM Pharma SpecialistsRecruiting
- Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
- Centro Multidisciplinario de Diabetes de PachucaRecruiting
- Unidad de Investigación Clínica y Atención Médica HEPA
- Centro de Investigacion Medica de Occidente, S.C.
- IMED Internal Medicine Clin TrialsRecruiting
- Clínica García Flores SCRecruiting
- Eukarya PharmaSiteRecruiting
- Medical Care and Research SA de CV
- EME RED Hospitalaria
- Investigacion En Salud Y Metabolismo Sc
- Lahoja. Asociacion Para La Investigacion Y La FarmacovigilanciaRecruiting
- Centro de Atención e Investigación Cardiovascular del PotosíRecruiting
- FAICIC S. de R.L. de C.V.Recruiting
- NBR PolskaRecruiting
- NZOZ Diab-Endo-MetRecruiting
- KLIMED Marek KlimkiewiczRecruiting
- Centrum Badan Klinicznych PI-House sp. z o.o.Recruiting
- Ambulatorium Barbara BazelaRecruiting
- Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-AkcyjnaRecruiting
- Centrum Medyczne Pratia KatowiceRecruiting
- NZOZ Salvia CMRecruiting
- Samodzielny Publiczny Szpital Kliniczny nr 1 SUMRecruiting
- Ponce Medical School Foundation Inc.Recruiting
- Clinical Research Management Group Inc. - Hospital San CristobalRecruiting
- Latin Clinical Trial CenterRecruiting
- Nemocnica s poliklinikou LucenecRecruiting
- Metabol KLINIKRecruiting
- MediVet s.r.o.Recruiting
- Human Care s.r.o.Recruiting
- Tatratrial s.r.o.Recruiting
- Areteus s.r.o.Recruiting
- MEDI-DIA s.r.o.Recruiting
- MediTaskRecruiting
- Hospital Universitario Virgen de la VictoriaRecruiting
- Hospital Quiron Infanta LuisaRecruiting
- Hospital Universitari Vall d'HebronRecruiting
- Hospital Universitario Marqués de ValdecillaRecruiting
- Hospital Virgen del CaminoRecruiting
- Hospital Virgen de las MontañasRecruiting
- Hospital Universitario Arnau de Vilanova de LleidaRecruiting
- Vithas Hospital SevillaRecruiting
- Hospital Universitario de La RiberaRecruiting
- Hospital General Universitario Gregorio MarañonRecruiting
- Hospital Universitario Virgen Del RocioRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Placebo Comparator
Retatrutide Dose 1
Retatrutide Dose 2
Placebo
Participants will receive retatrutide subcutaneously (SC).
Participants will receive retatrutide SC.
Participants will receive placebo.