Effect of a Progressive Treadmill Training Protocol for Parkinson's Disease
Parkinson Disease, Gait, Festinating, Fall Due to Loss of Equilibrium
About this trial
This is an interventional treatment trial for Parkinson Disease focused on measuring Parkinson Disease, Gait rehabilitation, Balance, Falls, Physiotherapy, Rehabilitation, Biomarkers, Raman spectroscopy, extracellular vesicles
Eligibility Criteria
Inclusion Criteria: Diagnosis of Parkinson's disease according to the diagnostic (POSTUMA criteria) Hoehn and Yahr Stage II-III Age>18 years One fall in the past 3 months/presence of postural instability /gait disturbance Able to walk for at least 5 minutes without assistance Stable drug therapy by at least 1 month Willingness to participate in the study, ability to understand and willingness to sign informed consent Exclusion Criteria: Other pathology concurrent with gait disturbance (symptomatic arthritis involving hip/knee/ankle, stroke outcomes, severe polyneuropathy) Cognitive impairment capable of interfering with rehabilitation procedures, estimated as a score less than 18.58 at the Montreal Cognitive Assessment (MoCA), row score corrected according to Aiello et al, 2022 Hallucinations Psychiatric disorder not controlled by current drug therapy Alcohol/drug use Uncompensated visual/auditory deficit that limits enjoyment of the cues provided by the AVR Communication deficit from any cause that impairs understanding of the task and the objectives of the intervention Recurrent episodes of severe orthostatic hypotension Severe cardiovascular diseases Patient undergoing other experimental protocol (patients regularly undergoing physical activity or sport will not be excluded)
Sites / Locations
- IRCCS Fondazione Don Gnocchi FirenzeRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
AVR Treadmill training with C-Mill
Conventional Treadmill training with C-Mill
Participants (N=30) will undergo the AVR Treadmill training intervention with 5 AVR applications named "Nature Island", "stepping stones", "walking area": "obstacles avoidance", and "track".
Participants (N=30) will undergo the "Traditional Treadmill" intervention.