Effects of Time-restricted Eating and Exercise Training on Skeletal Muscle Mass Quantity, Quality and Function in Postmenopausal Women With Overweight and Obesity
Menopause Related Conditions, Sarcopenia, Osteoporosis Postmenopausal
About this trial
This is an interventional treatment trial for Menopause Related Conditions focused on measuring Obesity, Overweight, Sarcopenia, Menopause, Exercise, Resistance Exercise, Physical activity, intramuscular adipose tissue, Visceral adipose tissue, Liver fat, Skeletal muscle mass, Muscle function, Muscle quality, Osteoporosis
Eligibility Criteria
Inclusion Criteria: Age between 50 and 65 years. Menopause (Phase +1a) Body mass index ≥25.0 and <40 kg/m2 or waist circumference > 94 cm. Weight stability (within 3% of screening weight) for >3 months prior to baseline. Sedentary lifestyle (<150 min/week of moderate-vigorous intensity exercise) for >3 months prior to baseline. Usual feeding window ≥12 hours. Exclusion Criteria: History of major adverse cardiovascular events, clinically significant renal, endocrine or neurological disease, bariatric surgery, HIV/AIDS, known inflammatory and/or rheumatologic disease, cancer or other medical condition in which fasting or exercise is contraindicated. Use of exogenous (sex) hormones (hormone replacement therapy). Type 1 or type 2 diabetes. Severe psychiatric disorders, eating disorders, sleep disorders or alcohol abuse. Regular use of medications or compounds that may affect study results. Participating in a weight loss or weight control program. Caregiver of a dependent person who requires frequent nighttime care/sleep interruptions. Shift workers with variable schedules (e.g., nighttime). Frequent travel across time zones during the study period. Fear of needles and claustrophobia of magnetic resonance imaging (MRI). Any medical situation that prevents the performance of MRI (pacemakers, prostheses, etc). Being unable to understand and accept the instructions or the objectives and protocol of the study.
Sites / Locations
- Universidad Pública de NavarraRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Active Comparator
Time Restricted Eating (TRE)
Time Restricted Eating (TRE) + Exercise
Caloric restriction (CR) + Exercise