A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight (TRIUMPH-1)
Obesity, Overweight, Knee Pain Chronic
About this trial
This is an interventional treatment trial for Obesity
Eligibility Criteria
Inclusion Criteria: Have body mass index (BMI) ≥30.0 kilograms per square meter (kg/m²), or ≥27.0 kg/m² with at least one of the following: hypertension dyslipidemia obstructive sleep apnea, or cardiovascular disease History of of at least one unsuccessful dietary effort to reduce body weight GOA1 Inclusion Criteria: Have index knee pain for >12 weeks prior to screening, and presence of index knee pain for >15 days over the previous month Have knee X-ray with moderate radiographic changes (Kellgren-Lawrence Grade 2 or 3) per central reading at screening Currently meets American College of Rheumatology (ACR) Criteria (clinical and radiological) for OA. GSA1 Inclusion Criteria: Previously diagnosed with OSA Have AHI ≥15 on polysomnography at screening (definition of moderate-to-severe OS) For participants not on positive airway pressure (PAP) therapy: unable or unwilling to use PAP therapy and have not used PAP for at least 4 weeks prior to screening. If on PAP therapy, have been on PAP therapy for at least 3 consecutive months prior to screening, and willing to temporarily stop using PAP therapy for approximately 7 days prior to each of the sleep study (PSG) visits. Exclusion Criteria: Have a self-reported or documented change in body weight >5 kg (11 pounds) within 90 days. Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening. Have a prior or planned surgical treatment for obesity. Have diabetes mellitus. Have family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2) Have had pancreatitis. GOA1 exclusion criteria Have had steroid joint injections within 90 days of screening. Have had other joint injections and procedures within 6 months of screening. Have joint disease other than osteoarthritis. GSA1 exclusion criteria Use stimulants (for example, modafinil, armodafinil, solriamfetol, pitolisant, amphetamine) less than 3 months prior to screening. Use hypnotics, mirtazapine, opioids, trazodone, and zonisamide less than 3 months prior to screening. Use a dental appliance or other device to treat OSA other than PAP therapy.
Sites / Locations
- Central Phoenix Medical ClinicRecruiting
- Arizona Research CenterRecruiting
- Medical InvestigationsRecruiting
- Valley ResearchRecruiting
- University of Colorado Anschutz Medical CampusRecruiting
- Chase Medical Research, LLCRecruiting
- Teradan Clinical Trials, LLCRecruiting
- Suncoast Research GroupRecruiting
- New Horizon Research CenterRecruiting
- Clinical Neuroscience SolutionsRecruiting
- Progressive Medical ResearchRecruiting
- NeuroTrials Research IncRecruiting
- North Georgia Clinical ResearchRecruiting
- East-West Medical Research InstituteRecruiting
- Northwestern UniversityRecruiting
- Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research CooperativeRecruiting
- Brengle Family MedicineRecruiting
- Cotton O'Neil Clinical Research CenterRecruiting
- MedVadis Research CorporationRecruiting
- Great Lakes Research Group, Inc.Recruiting
- StudyMetrix ResearchRecruiting
- Clinvest Research LLCRecruiting
- Palm Research Center TenayaRecruiting
- Rochester Clinical Research, Inc.Recruiting
- Carteret Medical GroupRecruiting
- Trial Management Associates - Wilmington - Floral ParkwayRecruiting
- Lillestol ResearchRecruiting
- Altoona Center For Clinical ResearchRecruiting
- Tribe Clinical Research, LLCRecruiting
- Tribe Clinical Research - SpartanburgRecruiting
- Vanderbilt Health One Hundred Oaks
- FutureSearch Trials of NeurologyRecruiting
- Juno ResearchRecruiting
- Advanced Research InstituteRecruiting
- Northwest Clinical Research CenterRecruiting
- Rainier Clinical Research CenterRecruiting
- Optimus Clinical ResearchRecruiting
- The AIM Centre / Hunter Diabetes CentreRecruiting
- Logan HospitalRecruiting
- Fusion Clinical ResearchRecruiting
- Nightingale ResearchRecruiting
- Emeritus ResearchRecruiting
- Barwon HealthRecruiting
- One Clinical Research
- CPCLINRecruiting
- CPQuali Pesquisa ClínicaRecruiting
- Hospital das Clinicas FMUSPRecruiting
- Aggarwal and Associates LimitedRecruiting
- Dr. Steven V. Zizzo Medicine Professional CorporationRecruiting
- Wharton Medical ClinicRecruiting
- Your Research NetworkRecruiting
- Bluewater Clinical Research Group Inc.Recruiting
- Canadian Phase OnwardRecruiting
- Centre de Recherche Clinique de LavalRecruiting
- Clinique de médecine Urbaine du Quartier LatinRecruiting
- C.I.C. Mauricie inc.Recruiting
- Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai KözpontRecruiting
- Regia Med KftRecruiting
- Medifarma 98 KftRecruiting
- DRC Gyógyszervizsgáló KözpontRecruiting
- Óbudai Egészségügyi CentrumRecruiting
- ClinDiab Kft.Recruiting
- Debreceni Egyetem Klinikai KozpontRecruiting
- Endolife Speciality HospitalsRecruiting
- Lady Hardinge Medical College
- Avron Hospitals
- Indian Institute of Diabetes
- Jothydev's Diabetes and Research Center
- Wockhardt Hospital - Mumbai Central
- Deenanath Mangeshkar Hospital & Research Centre
- Chellaram Diabetes Institute
- Lifepoint Multispeciality Hospital
- Eternal Heart Care Center and Research InstituteRecruiting
- Christian Medical College Vellore
- ILS Hospitals
- Postgraduate Institute of Medical Education & Research
- Gachon University Gil Medical Center
- Korea University Ansan HospitalRecruiting
- Hallym University Sacred Heart Hospital
- Hanyang University Guri HospitalRecruiting
- Seoul National University Bundang Hospital
- Ajou University Hospital
- Pusan National University Yangsan Hospital
- Nowon Eulji Medical Center, Eulji University
- Kangbuk Samsung Hospital
- Korea University Guro Hospital
- Kyungpook National University Hospital
- Eulji University Hospital
- Konyang University Hospital
- Ulsan University Hospital
- Centro de Investigacion en Artritis y Osteoporosis SC
- RM Pharma Specialists
- Clinica Omega
- Diseno y Planeacion en Investigacion Medica
- Clinica de Investigacion en Reumatologia y Obesidad S. C.
- Private Practice - Dr. Arechavaleta Granell Maria del Rosario
- Unidad de Investigación Clínica y Atención Médica HEPA
- Instituto de Diabetes, Obesidad y Nutricion
- Unidad biomedica avanzada monterrey
- EME RED Hospitalaria
- Kohler and Milstein Research S.A. de C.V.
- Centro de Atención e Investigación Clínica
- Investigacion En Salud Y Metabolismo S.C / Nutricion Clinica / Unidad de Base de Datos
- Arké SMO S.A de C.V
- INTERCORRecruiting
- CenterMed Lublin NZOZRecruiting
- Gabinety TERPARecruiting
- Medycyna KlinicznaRecruiting
- Centrum Badan Klinicznych PI-House sp. z o.o.Recruiting
- Centrum Kliniczno-BadawczeRecruiting
- Ambulatorium Barbara Bazela
- Centrum Zdrowia Metabolicznego Pawel BogdanskiRecruiting
- NZOZ Salvia CMRecruiting
- Specjalistyczna Praktyka Lekarska Diabetologia, Leczenie Cukrzycy i OtylosciRecruiting
- Ponce Medical School Foundation Inc.Recruiting
- DiabdanaRecruiting
- C.M.D.T.A. NeomedRecruiting
- Hightech Medical Services SRL-Centrul pentru Studiul MetabolismuluiRecruiting
- Gama DiamedRecruiting
- Cabinet Medical Dr.GeruRecruiting
- SC Minimed SRLRecruiting
- Diamed ObesityRecruiting
- Centrul Medical ConsultmedRecruiting
- Clinica KorallRecruiting
- Policlinica Astra SibiuRecruiting
- CHUAC-Complejo Hospitalario Universitario A CoruñaRecruiting
- Hospital Universitari Vall d'HebronRecruiting
- Hospital Universitario Marqués de ValdecillaRecruiting
- Hospital General Universitario de Valencia
- Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)Recruiting
- Changhua Christian Hospital
- Kaohsiung Medical University Chung-Ho Memorial HospitalRecruiting
- China Medical University Hospital
- National Cheng Kung University Hospital
- Rowden Surgery
- Layton Medical Centre
- Leicester General Hospital
- Panthera Biopartners - North LondonRecruiting
- Glasgow Royal Infirmary
- Heartlands Hospital
- Aintree University Hospital NHS Foundation Trust
- St Clare Medical Centre
- Panthera Biopartners - SheffieldRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Placebo Comparator
Retatrutide Dose 1
Retatrutide Dose 2
Retatrutide Dose 3
Placebo
Participants will receive retatrutide subcutaneously (SC).
Participants will receive retatrutide SC.
Participants will receive retatrutide SC.
Participants will receive placebo.