Effects of rTSMS Associated With Treadmill Training in Patients With Parkinson's Disease
Parkinson Disease, Gait Disorders, Neurologic
About this trial
This is an interventional treatment trial for Parkinson Disease focused on measuring Non-invasive brain stimulation, Parkinson's disease, Spinal cord stimulation, gait
Eligibility Criteria
Inclusion Criteria: Men and women over the age of 18; Participants with PD at Hoehn Yahr stages between 2 and 4 (moderate disease) while on-medication (i.e., at the time when their usual dopaminergic medication is clinically effective), whose primary symptom includes gait disturbance (score equal to or greater than 1 in subitem 2.12 of the MSD-UPDRS scale). Patients will be evaluated for the presence of freezing gait (freezing) through the Freezing of Gait Score (FOG-SCORE). While on on-medication, be able to walk independently for 30 meters or with a unilateral assistive device. Mini Mental State Examination (MMSE) score greater than or equal to 23. Sign the informed consent form. Exclusion Criteria: Patients with unstabilized psychiatric comorbidities; Individuals who have other neurological disorders, musculoskeletal, orthopedic, cardiovascular and respiratory disorders that may affect the ability to walk on the treadmill will be excluded. Individuals with labyrinthine problems, using medication that may interfere with balance and performance in tests and treadmill training will be excluded. Individuals who have undergone deep brain stimulation surgery or epidural spinal cord stimulation will be excluded. Patients with uncontrolled infection or other uncontrolled pre-existing medical conditions (eg uncontrolled diabetes, high blood pressure, symptomatic lung or heart disease); Concomitant treatment with other experimental drugs; Pregnant or breastfeeding women. Presence of chronic low back and lower limb pain. Patients who cannot walk without assistance (cane, crutch, walker) or help from another person. Patients with metal implants and a cardiac pacemaker. Patient with a history of neurosurgery.
Sites / Locations
- Hospital das Clínicas da Faculdade de Medicina da USPRecruiting
Arms of the Study
Arm 1
Arm 2
Sham Comparator
Active Comparator
Sham repetitive transpinal magnetic stimulation
Active repetitive transpinal magnetic stimulation
In the Sham group a coil will be positioned in the T2-T3 thoracic region disconnected to the stimulation device and the active coil will be positioned about 15 cm behind the patient, away from his field of vision, to provide sound stimulus.
In the Active group, the patient will receive intermittent theta burst stimulation (iTBS) in the T2-T3 region while seated using a circular magnetic coil positioned at 90º, handle facing to the right, connected to a magnetic stimulator.