Platelet Rich Plasma VS Platelet Fibrin Plasma in Treatment of Diabetes Foot Ulcer：a Randomized Controlled Trial

Inclusion Criteria: The patient is aged 18-80 years old; Diagnosed as type 1 or type 2 diabetes according to the World Health Organization standard, blood sugar has been controlled before enrollment, and the level of Glycated hemoglobin HbA1c is less than 10%; diabetes wounds with poor healing or prolonged healing need standard wound treatment; There is no disseminated infection or the disseminated infection has been controlled; After preparing the wound bed, the condition for using platelet plasma to close the wound is met; Voluntarily sign an informed consent form; Exclusion Criteria: Severe diseases such as acute myocardial infarction, heart failure, hepatitis, shock, and respiratory failure have not been corrected yet; Severe ischemia of the wound surface, unable to seek medical attention or not yet corrected; Uncontrolled systemic or disseminated infections; Blood glucose is out of control or not yet effectively controlled; Blood system diseases with uncorrected coagulation dysfunction or platelet dysfunction; There is active bleeding inside the wound, and routine basic treatment plans cannot be implemented; Platelets ≤ 80 × 10^9, hemoglobin<90g/L; Patients with advanced malignant tumors; Active period of autoimmune diseases; The patient is unable to cooperate or has mental disorders; According to the judgment of the researchers, the patient has a clear and irremovable cause that affects wound healing, which is not suitable for this study or cannot comply with the requirements of this study.