Pain in Parkinson's Disease: Exploration of the Serotonin System in Positron Emission Tomography (PET [18F]-MPPF) (PD-Pain)
Parkinson Disease
About this trial
This is an interventional basic science trial for Parkinson Disease focused on measuring PD-related central pain, PET [18F] MPPF, serotoninergic system, multimodal imaging, pain threshold
Eligibility Criteria
Inclusion Criteria: Patients with PD defined according to United Kingdom Parkinson's Disease Brain Bank (UKPDSBB) criteria Patients with stable anti-parkinsonian treatment for at least 4 weeks prior to inclusion Patients with a Montreal Cognitive Assessment (MoCA) score > 25 Patients with a Hospital Anxiety and Depression Scale (HADS)-D score ≥ 11 Person affiliated or benefiting from a social security scheme. Free, informed and written consent signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research). • For patients with pain Patients with PD-related central pain defined according to the criteria of Marques et al, 2019 Patients with chronic central pain (i.e. present for at least 3 months) Patients who have average pain over the previous month according to a VAS ≥ 4. • For patients without pain Patients who do not have pain defined as VAS ≤ 4, meaning that it does not interfere with daily activity. Exclusion Criteria: Patients treated with second line therapy Patients with a history of significant psychiatric pathology according to the investigator Patients treated with drugs interacting with 5HT1A receptors in the previous 4 weeks Patients with contraindication to MRI Patients refusing to be informed of an abnormality discovered during brain imaging Patients with dyskinesias judged by the investigator to be disabling for imaging. Patients under guardianship or other legal protection, deprived of their liberty by judicial or administrative decision Pregnant woman, breastfeeding woman
Sites / Locations
- Centre Hospitalier Universitaire de Toulouse
Arms of the Study
Arm 1
Arm 2
Other
Other
PD patients with central chronic pain
PD patients without pain
Patients from both groups will receive the same interventions, the difference between groups is the eligibility criteria. In this arm only patients presenting central chronic pain will be included
Patients from both groups will receive the same interventions, the difference between groups is the eligibility criteria. In this arm only patients without central chronic pain will be included