Delaying the Onset of Nearsightedness Until Treatment Study (DONUT)

University of Houston, State University of New York, Pennsylvania College of Optometry, Southern California College of Optometry at Marshall B. Ketchum University, University of California, Berkeley, Stanford University, Case Western Reserve University, Illinois College of Optometry, Indiana University, New England College of Optometry, University of the Incarnate Word, Southern College of Optometry, University of Missouri, St. Louis

Participants eligible for the study will be randomized to one of three concentrations of atropine and followed for a month.

Participants will be identified through screening that fit the criteria of a pre-myopic child, which will depend on age and the amount of refractive error at that time. These children will be randomized for a pilot study measuring compliance in nightly eye drop administration. The outcome will be thirty days after randomization, and will assess whether or not there is a difference in compliance between one of three dosages of atropine (0.01%, 0.03%, and 0.05%).

De-identified bottles will be sent to the sites with randomization codes. The key will be kept at the data coordinating center.

Inclusion Criteria: Age: 6-11 years Refractive error measured in spherical equivalent, one eye meets criterion 6 years old: 0.50 to +0.38 7 years old: 0.50 to +0.25 8-11 years old: 0.50 to plano Anisometropia: spherical equivalent <1.50 D Astigmatism: <1.50 in both eyes Myopia: Less myopic than -0.74 D, both eyes Exclusion Criteria: ● Myopic