Peripheral Avascular Retina in Retinopathy of Prematurity
Retinopathy of Prematurity
About this trial
This is an interventional treatment trial for Retinopathy of Prematurity
Eligibility Criteria
Inclusion Criteria: Patients with persistent peripheral avascular retina attending follow up till the age of 18 months in the core study whether; regressed ROP: children with regressed ROP who had not received any treatment. IVI treatment ROP: children with a history of threshold ROP treated with IVI of anti-VEGF agents. Exclusion Criteria: Eyes with previous laser therapy. Eyes with any other pathology, other than ROP. Eyes with stage 4 or 5 ROP. Patients with hypersensitivity to iodinated contrast media, liver and renal insufficiency, history of asthma. Patients who will show hypersensitivity reaction to fluorescein angiography will be excluded from the thesis. Patients unfit for general anesthesia.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
No Intervention
Active Comparator
Peripheral avascular retina of ROP with no leakage.
Peripheral avascular retina of ROP with active leakage.
If there is no active leakage detected by FFA, patients would be observed. The follow-up period: FFA will be done at the age of 18 months we will repeat FFA every 6 months and fundus examination with color photography every 3 months till the age of 3 years of children.
If there is evidence of active leakage by FFA The confluent laser burns will be applied to the entire avascular retina from the ridge to the ora serrata for 360 through the transpupillary route.