A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction
Carotid Artery Diseases, Carotid Artery Stenosis
About this trial
This is an interventional treatment trial for Carotid Artery Diseases focused on measuring Carotid artery diseases, Carotid artery stenosis, Carotid artery surgery, Lithium, Neurocognitive disorders, Postoperative cognitive disorders, Postoperative delirium, Emergence delirium, Agitation, Stroke, Neuroinflammation
Eligibility Criteria
Inclusion Criteria:
- age > 18 years
- elective carotid artery surgery
- general anesthesia
- written informed consent
Exclusion Criteria:
- urgent surgery
- recent ( < 1 month) overt stroke
- Mini-mental State Examination < 20 points
- The presence of any mental disorder according to the International Classification of Diseases 11th Revision which is confirmed by a psychiatrist.
- The presence of any neuromuscular disease according to the International Classification of Diseases 11th Revision
- Hypersensitivity or known allergy to lithium carbonate
- History of seizure disorder
- History of leukemia
- Estimated glomerular filtration rate < 30 ml/min/1.73 m2
- Left ventricular ejection fraction < 30%
- Heart failure equal 3 or 4 class according to the New York Heart Association Functional Classification
- Pregnant or breast-feeding women
- Inability to undergo a preoperative assessment for any reason
- Previously enrolled in this trial
Sites / Locations
- Demikhov Municipal Clinical Hospital 68Recruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Lithium
Placebo
In preoperative period patients will take 300mg of lithium carbonate on 1-1-1 regimen during 2 days prior to surgery. On the day of surgery, they will take 300mg of lithium carbonate 2 hours before surgery. After the surgery, patients will take 300mg of lithium carbonate in the afternoon and 300mg of lithium carbonate in the evening.
In preoperative period patients will take placebo on 1-1-1 regimen during 2 days prior to surgery. On the day of surgery, they will take placebo 2 hours before surgery. After the surgery, patients will take placebo in the afternoon and in the evening.