A Study of SARS CoV-2 Infection and Potential Transmission in Individuals Immunized With Moderna COVID-19 Vaccine (CoVPN 3006)
SARS-CoV-2 Infection
About this trial
This is an interventional prevention trial for SARS-CoV-2 Infection focused on measuring SARS-CoV-2
Eligibility Criteria
Inclusion Criteria for Immediate Vaccination and Standard of Care Groups:
- Willingness to be followed for the planned duration of the study.
- Agrees to allow study staff to access school SARS-CoV-2 testing data and outcomes, if applicable.
- Ability and willingness to provide informed consent.
- Assessment of understanding: volunteer demonstrates understanding of this study; completes a questionnaire with demonstration of understanding of all questionnaire items answered incorrectly.
- Willing to be randomized to either immediate vaccination or standard of care group and comply with planned study procedures
- Agrees not to enroll in another study of an investigational research agent until the end of the study.
- Access to device and internet for completion of study procedures.
Exclusion Criteria for Immediate Vaccination and Standard of Care Groups:
- Acutely ill 72 hours prior to or at screening. Volunteers meeting this criterion may be rescheduled within the relevant window periods. Participants with minor illnesses can be enrolled at the discretion of the investigator.
- Blood products, systemic immunoglobulins, or monoclonal antibodies (including against SARS-CoV-2) received within 90 days before first vaccination.
- Investigational research agents received within 30 days before first vaccination.
- Self-reported known history of SARS-CoV-2 infection.
- Prefers to receive COVID-19 vaccination immediately, (These volunteers to be referred to community resources for vaccination).
- Prior administration of a coronavirus (SARS-CoV-2, SARS-CoV, MERS-CoV) vaccine or current/planned simultaneous participation in another interventional study to prevent or treat COVID-19.
- Immunosuppressive medications received within 168 days before first vaccination (not exclusionary: [1] corticosteroid nasal spray; [2] inhaled corticosteroids; [3] topical corticosteroids for mild, uncomplicated dermatologic condition; or [4] a single course of oral/parenteral prednisone or equivalent at doses < 60 mg/day and length of therapy < 11 days with completion at least 30 days prior to enrollment).
- Clinically significant medical condition, physical examination findings, or past medical history with clinically significant implications for current health. A clinically significant condition or process includes but is not limited to a process that would affect the immune response (well-controlled human immunodeficiency virus infection is allowed), or any condition specifically listed among the exclusion criteria below.
- Any medical, psychiatric, occupational, or other condition that, in the judgment of the investigator, would interfere with, or serve as a contraindication to, protocol adherence, assessment of safety or reactogenicity, or a volunteer's ability to give informed consent.
- Bleeding disorder (eg, factor deficiency, coagulopathy, or platelet disorder requiring special precautions).
- Asplenia: any condition resulting in the absence of a functional spleen.
- History of angioedema or anaphylaxis, including to vaccines or vaccine components (not exclusionary: angioedema or anaphylaxis with known trigger and no episodes within five years.).
- History of generalized urticaria within past five years.
Inclusion Criteria for Vaccine Declined Group:
- Ability and willingness to provide informed consent.
- Prefers not to receive COVID-19 vaccine.
- Willingness to be followed for the planned duration of the study.
- Assessment of understanding: volunteer demonstrates understanding of this study; completes a questionnaire with demonstration of understanding of all questionnaire items answered incorrectly.
- Access to device and internet for completion of study procedures.
Exclusion criteria for Vaccine Declined Group:
- Prior administration of a coronavirus (SARS-CoV-2, SARS-CoV, MERS-CoV) vaccine or current/planned simultaneous participation in another interventional study to prevent or treat COVID-19 (participation in studies of other investigational research agents allowed).
- Any medical, psychiatric, occupational, or other condition that, in the judgment of the investigator, would interfere with, or serve as a contraindication to, protocol adherence, or a volunteer's ability to give informed consent.
Sites / Locations
- Alabama CRS
- Headlands Research Scottsdale
- AMR Phoenix
- University of Arizona
- Charles Drew University
- UC Davis
- University of California, San Diego
- University of Colorado- Boulder
- JEM Headlands LLC
- University of Florida
- UF CARES
- Orlando Immunology Center CRS
- Headlands Research Sarasota
- University of South Florida
- Morehouse University
- The Hope Clinic of the Emory Vaccine Center CRS
- Champaign-Urbana Public Health District
- Rush University CRS
- Northwestern University
- Indiana University
- Univ, of Kansas School of Medicine CRS
- University of Kentucky
- Centex Studies, Inc. - Lake Charles
- University of Maryland College Park
- Fenway Health (FH) CRS
- Wayne State - Harper Hospital
- University of Minnesota
- Columbia - Missouri VTEU
- Washington University Therapeutics CRS
- University of Nebraska
- AMR Las Vegas
- University of New Mexico
- Bronx Prevention Research Center CRS
- NYU Long Island Vaccine Center
- NYU Bellevue Vaccine Center
- Harlem Prevention Center CRS
- New York Blood Center CRS
- Stony Brook University
- University of North Carolina
- Wake Forest University
- The Miriam Hopsital CRS
- Clemson University
- Vanderbilt Vaccine CRS
- Texas Tech
- Centex Studies, Inc. - Brownsville
- Texas A&M University
- Centex Studies, Inc. - Houston
- Centex Studies, Inc. - Westfield
- Texas A&M - Kingsville
- University of Virginia
- University of Washington
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
No Intervention
Immediate Vaccination
Standard of care
Vaccine Declined
Participants will receive Moderna COVID-19 Vaccine in 100 mcg dose given as 0.5 ml Intramuscular into the deltoid muscle on Day 1 and Day 29.
Participants will receive Moderna COVID-19 Vaccine in 100 mcg dose given as 0.5 ml Intramuscular into the deltoid muscle on Day 113 and Day 141.
Participants who prefer not to be vaccinated, If requested, participant will be offered vaccine if they have not received vaccine outside of the study