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Auto-regulated Resistance-training for Older Adults

Primary Purpose

Sarcopenia

Status
Recruiting
Phase
Not Applicable
Locations
Canada
Study Type
Interventional
Intervention
Resistance training
Sponsored by
University of Saskatchewan
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Sarcopenia

Eligibility Criteria

50 Years - undefined (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • Males and females 50 years of age or greater

Exclusion Criteria:

  • Inability to safely perform squat and bench press exercises as determined by the Get Active Questionnaire

Sites / Locations

  • University of SaskatchewanRecruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Active Comparator

Arm Label

Subjective auto-regulation training

Objective auto-regulation training

Traditional standardized training

Arm Description

Participants complete their resistance-training sets to termination based on rating of perceived exertion

Participants complete their resistance-training sets to termination based on reaching a critical slow velocity

Participants complete their resistance-training sets by lifting a prescribed percentage of their estimated one-repetition maximum (as determined from baseline four-repetition maximum strength testing)

Outcomes

Primary Outcome Measures

Change from baseline in bench press strength
Change from baseline in squat strength

Secondary Outcome Measures

Change from baseline in muscle thickness
Muscle thickness will be determined for the quadriceps, hamstrings, triceps, and pectoralis (males only)
Change from baseline in knee extension strength
Change from baseline for time to sit and stand from a chair five times
Change from baseline in time to complete the "timed up and go" (TUG) test
Time to stand from a chair, walk around a cone (3 meters) and sit back down in the chair
Change from baseline in time to climb 10 stairs
Change from baseline in time to walk 10 meters

Full Information

First Posted
October 11, 2022
Last Updated
June 2, 2023
Sponsor
University of Saskatchewan
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1. Study Identification

Unique Protocol Identification Number
NCT05580913
Brief Title
Auto-regulated Resistance-training for Older Adults
Official Title
Auto-regulated Resistance-training for Improving Strength in Older Adults
Study Type
Interventional

2. Study Status

Record Verification Date
June 2023
Overall Recruitment Status
Recruiting
Study Start Date
October 15, 2022 (Actual)
Primary Completion Date
August 31, 2023 (Anticipated)
Study Completion Date
August 31, 2023 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Saskatchewan

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
This research study is comparing the effect of traditional standardized, subjective auto-regulated, and objective auto-regulated resistance training on physiological adaptations and performance measures in adults aged 50 years or older. Traditional standardized resistance training involves prescribing resistance training as a percentage of an individual's one-repetition maximum (i.e., the maximal weight they can lift one time). Auto-regulated resistance training involves adjusting resistance training based on an individual's performance during the session. Subjective auto-regulation involves the resistance trainee providing a subjective rating of perceived exertion based on repetitions in reserve (on a scale from 1 - 10) to adjust the resistance training prescription. A rating of perceived exertion of 10 would mean that the resistance trainee believes that they have provided maximal effort and believes that they could not have performed an additional repetition during the set nor increased the load. Objective auto-regulation involves adjusting the resistance training prescription from a linear position transducer (a device that has a string that attaches to the barbell and provides a velocity value on each repetition). A slower velocity value means a higher perceived exertion and load used, whereas a faster velocity value means a lower perceived exertion and load used.
Detailed Description
Auto-regulated resistance training has emerged as a resistance training paradigm to individualize programming; however, it remains to be elucidated whether auto-regulated resistance training provides a greater benefit than traditional standardized resistance training on physiological adaptations and performance outcomes in older adults. Traditional resistance training involves prescription of intensity as a percentage of the maximal amount of weight an individual can lift (for example, a resistance of 70% of maximal strength is a weight equal to 70% of the maximal weight a person can lift one time. An individual with this prescription would lift this weight for a number of repetitions to failure; i.e. usually 8-10 repetitions). Auto-regulation can be done two ways: "Subjective" auto-regulation involves lifting a weight for a number of repetitions until the individual reaches a certain "rating of perceived exertion". The rating of perceived exertion is on a scale of 1-10, with 10 being the most difficult or maximal exertion. For example, if one was prescribed a rating of perceived exertion of 8 they would lift a weight for a given number of repetitions until they believed they were at an 8/10 on the scale and had 2 repetitions left before failing. "Objective" auto-regulation involves lifting a weight for a given number of repetitions until a predetermined velocity of lifting is reached. For example, once someone starts to get fatigued while performing repeated lifting, the velocity of lifting will slow down. Once they have reached a critical slow velocity, the exercise would be stopped. There is some evidence that auto-regulation improves muscular strength to a greater extent than traditional resistance training in healthy populations. The research design is a prospective randomized trial comparing three training protocols in 30 participants. Participants will be randomized into one of three groups (n = 10 each), with matching on baseline strength: traditional standardized, subjective auto-regulated, and objective auto-regulated. Training will be twice per week for 12 weeks. Measures include strength assessments, muscle size, and performance of functional tasks.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Sarcopenia

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
30 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Subjective auto-regulation training
Arm Type
Experimental
Arm Description
Participants complete their resistance-training sets to termination based on rating of perceived exertion
Arm Title
Objective auto-regulation training
Arm Type
Experimental
Arm Description
Participants complete their resistance-training sets to termination based on reaching a critical slow velocity
Arm Title
Traditional standardized training
Arm Type
Active Comparator
Arm Description
Participants complete their resistance-training sets by lifting a prescribed percentage of their estimated one-repetition maximum (as determined from baseline four-repetition maximum strength testing)
Intervention Type
Behavioral
Intervention Name(s)
Resistance training
Intervention Description
12 weeks of resistance-training performed two times per week
Primary Outcome Measure Information:
Title
Change from baseline in bench press strength
Time Frame
baseline, 12 weeks
Title
Change from baseline in squat strength
Time Frame
baseline, 12 weeks
Secondary Outcome Measure Information:
Title
Change from baseline in muscle thickness
Description
Muscle thickness will be determined for the quadriceps, hamstrings, triceps, and pectoralis (males only)
Time Frame
Baseline, 12 weeks
Title
Change from baseline in knee extension strength
Time Frame
Baseline, 12 weeks
Title
Change from baseline for time to sit and stand from a chair five times
Time Frame
Baseline, 12 weeks
Title
Change from baseline in time to complete the "timed up and go" (TUG) test
Description
Time to stand from a chair, walk around a cone (3 meters) and sit back down in the chair
Time Frame
Baseline, 12 weeks
Title
Change from baseline in time to climb 10 stairs
Time Frame
Baseline, 12 weeks
Title
Change from baseline in time to walk 10 meters
Time Frame
Baseline, 12 weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
50 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Males and females 50 years of age or greater Exclusion Criteria: Inability to safely perform squat and bench press exercises as determined by the Get Active Questionnaire
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Philip Chilibeck, PhD
Phone
306-966-1072
Email
phil.chilibeck@usask.ca
Facility Information:
Facility Name
University of Saskatchewan
City
Saskatoon
State/Province
Saskatchewan
ZIP/Postal Code
S7N5B2
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Philip Chilibeck, PhD
Phone
306-966-1072
Email
phil.chilibeck@usask.ca
First Name & Middle Initial & Last Name & Degree
Scotty Butcher, PhD
First Name & Middle Initial & Last Name & Degree
Landyn Hickmott, MSc

12. IPD Sharing Statement

Plan to Share IPD
No

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Auto-regulated Resistance-training for Older Adults

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