Basil Extract (Ocimum Basilicum) in the Management of Recurrent Aphthous Stomatitis (RCT)
Oral Ulcer
About this trial
This is an interventional treatment trial for Oral Ulcer focused on measuring Aphthous Stomatitis, basil extract, endocan marker
Eligibility Criteria
Inclusion Criteria:
- age > 18 years;
- a clear history of RAS (recurrent apthous stomatitis) occurring no less than four times a year;
- presentation with one or two ulcers measuring 10 mm in diameter for 48 hours and yet to receive treatment;
- ulcers that took > 5 days to resolve without treatment.
Exclusion Criteria:
- had underlying systemic disease(s) or a history of immunologic disorder(s);
- were taking immunomodulatory agents or systemic nonsteroidal anti-inflammatory drugs < 1 month before study commencement;
- are smokers;
- are pregnant;
- had a history of abusing drugs or alcohol;
- could not provide written informed consent
Sites / Locations
- Malak Yousef Mohamed ShoukhebaRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Placebo Comparator
Sham Comparator
basil extract mucoadhesive gel
mucoadhesive placebo gel
healthy patients
10 patients treated with mucoadhesive gel containing 2% of basil extract 4 times per day (test group) for 20 min after every meal and before going to bed.
10 patients treated by mucoadhesive gel without drug which was used as placebo (contains tragacanth gum, alcohol, sodium benzoate, and distilled water) 4 times per day
10 healthy patients will be selected to participate in the study to test the salivary level of endocan in the healthy individuals (negative control group)