Back to resultsBlood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle (BRAIN-M)
Primary Purpose
Aging, Cognitive Decline, Sarcopenia
Status
Recruiting
Phase
Not Applicable
Locations
Lithuania
Study Type
Interventional
Intervention
BFRT
MDRT
Sponsored by
About this trial
This is an interventional treatment trial for Aging focused on measuring Aging, Motor control, Cognitive function, Neuroplasticity, Brain health, Muscular fitness, Exerkines, Myokines, (Neuro)inflammation
Eligibility Criteria
Inclusion Criteria: healthy male older adults able to speak and read fluent Lithuanian living in community during the study Exclusion Criteria: cognitive and neurological disorders (e.g. dementia, stroke, Parkinson, multiple sclerosis) previous lower extremity injury diabetes mellitus type I or II no oncologic disease no bone fractures in the previous year deep vein thrombosis cardiovascular disorders (e.g. congestive heart failure, angina pectoris, uncontrolled arrhythmia, history of myocardial infarction or coronary bypass grafting in the past year) obesity (BMI >30kg/m²) chronic fatigue, chronic headache, or chronic dizziness ineligibility to MRI scanning (e.g. due to claustrofobia or metal implants) The participants should not be engaged in any regular exercise programme during the previous 6 months (according to IPAQ), but able to perform 10 sit-ups Any other consideration that interferes with the study aims and/or risk to the participant, at the discretion of the researcher
Sites / Locations
- Lithuanian Sports UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm Type
Experimental
Experimental
No Intervention
Arm Label
Blood flow restriction training (BFRT)
Muscle damaging resistance training (MDRT)
Control group
Arm Description
Participants will engage in a supervised 12-week lower extremity resistance exercise program, 2 times per week. BFRT will be at an intensity of 40% of 1RM with an occlusive cuff placed at the proximal end of both lower extremities to restrict the return of blood flow. The cuff will be inflated to 50% of the limb occlusion pressure in the first week, which will be increased with 10% every week during the first 4 weeks to reach a maximum of 80% limb occlusion pressure on week 4 that will be kept for the remaining 9 weeks of the program. Each exercise will be performed for 4 sets of 12 repetitions with a 30-second rest period between sets and 3 minutes rest between exercises without occlusion.
Participants will engage in a supervised 12-week lower extremity resistance exercise program, 2 times per week. MDRT will be at an intensity of 80% or 120% of 1RM. The first session will be at 120% 1RM and consist of eccentric-only exercises. The concentric phase of the movement will be supported completely by a coach. The eccentric phase of the movement will be accentuated by increasing the time under tension to six seconds. Each exercise will be performed for 4 sets of 4 repetitions with 2 minutes rest between sets and 3 minutes rest between exercises. The eccentric-only exercise session will be followed by 2 (after the first session) or 3 (after all other sessions) concentric-only exercise sessions at 80% of 1RM. Here, the eccentric phase of the movement will be supported completely by a coach. In the 12 week period, there will be a total of seven eccentric-only exercise sessions.
Control group will be asked to maintain their usual lifestyle.
Outcomes
Primary Outcome Measures
Change in cognitive function on the Switching task (executive function)
The switching task is a complex task where subjects need to switch (executive function) between a manikin task (visuospatial skill, attention and problem solving) and a mathematical computation task (mathematical computation skill, concentration and working memory).
Secondary Outcome Measures
Change in cognitive function on the 2-Choice Reaction time (processing speed), Go/No-Go (inhibition) or 6 letter Memory Search (memory) test
Cognitive functioning will be assessed with the Automated Neuropsychological Assessment Metrics 4 (ANAM4) cognitive test battery, testing several cognitive domains.
Changes in lactate levels
Capillary lactate levels will be measured in the acute exercise test.
Changes in blood serum levels of TNFalpha and syndecan
We will use enzyme-linked immunosorbent assays (ELISAs) to measure acute changes in TNFalpha, and syndecan before and after the first exercise bout.
Changes in blood plasma levels of BDNF
We will use enzyme-linked immunosorbent assays (ELISAs) to measure acute and chronic changes in BDNF before and after the first exercise bout; and after 12 weeks intervention
Changes in blood serum levels of IGF-1, IL-6 and kynurenine
We will use enzyme-linked immunosorbent assays (ELISAs) to measure chronic changes in IGF-1, IL-6 and kynurenine before and after 12 weeks intervention
Changes in blood CK levels
Blood CK levels will be measured in the MDRT group 48 hours after each eccentric-only training session to assess the muscle damaging effect/repeated bout effect.
Changes in muscle contractile characteristics (with tensiomyography (TMG))
Muscle involuntary contractile characteristics of the lower-limb muscles-the rectus femoris (RF), vastus medialis (VM), vastus lateralis (VL), biceps femoris (BF), semitendinosus (ST), tibialis anterior (TA), gastrocnemius medialis (GM) and gastrocnemius lateralis (GL)-will be recorded by measuring the response of these muscles to an induced electric stimulus (provoked by two self-adhesive electrodes) using TMG equipment on both the left and right lower extremities.
Changes in BMI
Weight and height will be combined to report BMI in kg/m^2
Changes in body fat %
body fat % will be measured using bio-impedance analysis (Tanita)
Changes in SMI
Skeletal muscle mass index (SMI, kg/m^2) will be measured using bio-impedance analysis (Tanita)
Changes in fat free mass
Fat free mass (kg) will be measured using bio-impedance analysis (Tanita)
Changes in patellar tendon crossectional area
Ultrasound will be used to assess the crossectional area (cm^2) of the pattella tendon
Changes in patellar tendon stiffness
While producing isometric knee extension force, ultrasound will be used to assess patellar tendon distension, which is a measure of tendon stiffness.
Changes in quadriceps muscle fascicle length
Ultrasound will be used to quantify muscle geometrical properties such as fascicle length (cm).
Changes in quadriceps muscle fascicle angle
Ultrasound will be used to quantify muscle geometrical properties such as fascicle angle (°).
Changes in quadriceps muscle thickness
Ultrasound will be used to quantify muscle geometrical properties such as quadriceps muscle thickness.
Changes in quadriceps muscle cross-sectional area
MRI will be used to measure muscle cross-sectional volume changes of the quadriceps muscles
Changes in quadriceps muscle fiber type
H-MRS (proton magnetic resonance spectroscopy) will be used to measure fiber type in the quadriceps muscle
Changes in quadriceps muscle intramuscular fat
H-MRS (proton magnetic resonance spectroscopy) will be used to measure intramuscular fat in the quadriceps muscle
Changes in brain gray matter volume (with magnetic resonance imaging)
MRI will be used to measure changes in gray matter volume using T1 images
Changes in brain white matter volume (with magnetic resonance imaging)
MRI will be used to measure changes in white matter integrity using DTI sequence
Changes in brain neural integrity (with proton magnetic resonance spectroscopy)
H-MRS will be used to measure changes in N-acetylaspartate levels in specific brain regions: right dorsolateral prefrontal cortex, left hippocampus and left primary sensorimotor cortex.
Changes in brain neuroinflammation (with proton magnetic resonance spectroscopy)
H-MRS will be used to measure changes in myo-inositol levels in specific brain regions: right dorsolateral prefrontal cortex, left hippocampus and left primary sensorimotor cortex.
Changes in brain neuroplasticity marker (with proton magnetic resonance spectroscopy)
H-MRS will be used to measure changes in Glx in specific brain regions: right dorsolateral prefrontal cortex, left hippocampus and left primary sensorimotor cortex.
Changes in balance (with posturography on Kistler platform)
Balance will be assessed in four different positions (two legs stance vs Romberg stance with eyes open vs closed) with or without a cognitive task to measure dual task effects.
Changes in handgrip strength
Handgrip strength will be measured using Jamar dynamometry
Changes in maximal isometric strength (with Biodex)
Knee extension/flexion maximal isometric strength (N) will be measured using Biodex.
Changes in isokinetic peak torque (with Biodex)
Knee extension/flexion isokinetic peak torque measurements will be done at 60°/s
Changes in rate of force development (with Biodex)
Rate of force development will be measured during maximal knee extension/flexion movement.
Changes in physical performance (with the Fitness Fullerton Test battery for the Senior)
Determination of motor control tasks relevant to daily life activities. A selection of tests, including the sit-to-stance test, timed up-and-go test, and other physical tests
Changes in subjective quality of life (patient reported outcome questionnaires)
Quality of life will be assessed using the World Health Organisation 100 (WHO 100) questionnaire
Changes in nutrition (patient reported outcome questionnaires)
We will use a selection of patient reported outcome measures to evaluate their nutrition (using the Actual nutrition registration questionnaire).
Changes in subjective sleep quality (patient reported outcome questionnaires)
We will use a selection of patient reported outcome measures to evaluate their quality of sleep (using the Stanford sleep quality scale).
Changes in reported physical activity levels (patient reported outcome questionnaires)
We will assess physical activity levels using the International Physical Activities Questionnaire (IPAQ)
Full Information
NCT ID
NCT05744167
First Posted
September 8, 2022
Last Updated
February 15, 2023
Sponsor
Lithuanian Sports University
Collaborators
Research Council of Lithuania, Lithuanian University of Health Sciences, Maastricht University, Vrije Universiteit Brussel, KU Leuven, Wingate Institute
1. Study Identification
Unique Protocol Identification Number
NCT05744167
Brief Title
Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle
Acronym
BRAIN-M
Official Title
Resistance Training and Muscle - Brain Crosstalk
Study Type
Interventional
2. Study Status
Record Verification Date
February 2023
Overall Recruitment Status
Recruiting
Study Start Date
October 15, 2022 (Actual)
Primary Completion Date
June 1, 2023 (Anticipated)
Study Completion Date
December 31, 2023 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Lithuanian Sports University
Collaborators
Research Council of Lithuania, Lithuanian University of Health Sciences, Maastricht University, Vrije Universiteit Brussel, KU Leuven, Wingate Institute
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Product Manufactured in and Exported from the U.S.
Yes
Data Monitoring Committee
No
5. Study Description
Brief Summary
BRAIN-M is a randomized controlled trial designed to examine the effects of a single bout or 12 weeks of blood-flow restriction training or high-intensity resistance training on cognitive function, brain health, muscular properties and physical performance in healthy older men 60-75 years old.
Detailed Description
The BRAIN-M project is driven by the idea that understanding the mechanisms through which muscle and brain interact could offer new approaches to magnifying the beneficial and detrimental effects of exercise training on health at older age. Specifically, the investigators aim at identifying brain, blood, and muscle biomarkers that could serve as predictors of response to exercise training at either cognitive, brain, muscle or physical performance levels and study the associations between biomarkers in order to suggest a physiological model of brain-muscle and muscle-brain crosstalk in ageing. 60 male older adults (60-75y old) will be included in either 12 weeks of high-intense blood-flow restriction training (n = 20), muscle damaging resistance training (n = 20) or no exercise (n = 20). The control group will be asked to maintain their usual lifestyle.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Aging, Cognitive Decline, Sarcopenia, Frailty, Muscle Degeneration, Physical Disability
Keywords
Aging, Motor control, Cognitive function, Neuroplasticity, Brain health, Muscular fitness, Exerkines, Myokines, (Neuro)inflammation
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
InvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
60 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Blood flow restriction training (BFRT)
Arm Type
Experimental
Arm Description
Participants will engage in a supervised 12-week lower extremity resistance exercise program, 2 times per week. BFRT will be at an intensity of 40% of 1RM with an occlusive cuff placed at the proximal end of both lower extremities to restrict the return of blood flow. The cuff will be inflated to 50% of the limb occlusion pressure in the first week, which will be increased with 10% every week during the first 4 weeks to reach a maximum of 80% limb occlusion pressure on week 4 that will be kept for the remaining 9 weeks of the program. Each exercise will be performed for 4 sets of 12 repetitions with a 30-second rest period between sets and 3 minutes rest between exercises without occlusion.
Arm Title
Muscle damaging resistance training (MDRT)
Arm Type
Experimental
Arm Description
Participants will engage in a supervised 12-week lower extremity resistance exercise program, 2 times per week. MDRT will be at an intensity of 80% or 120% of 1RM. The first session will be at 120% 1RM and consist of eccentric-only exercises. The concentric phase of the movement will be supported completely by a coach. The eccentric phase of the movement will be accentuated by increasing the time under tension to six seconds. Each exercise will be performed for 4 sets of 4 repetitions with 2 minutes rest between sets and 3 minutes rest between exercises. The eccentric-only exercise session will be followed by 2 (after the first session) or 3 (after all other sessions) concentric-only exercise sessions at 80% of 1RM. Here, the eccentric phase of the movement will be supported completely by a coach. In the 12 week period, there will be a total of seven eccentric-only exercise sessions.
Arm Title
Control group
Arm Type
No Intervention
Arm Description
Control group will be asked to maintain their usual lifestyle.
Intervention Type
Behavioral
Intervention Name(s)
BFRT
Intervention Description
Following a warm-up of 10 min, subjects in the experimental group will undergo BFRT for two times per week, consisting of lower extremity exercises (leg press, knee extension, knee flexion). BFRT will be at 40% of 1 repetition maximum (1RM); The volume % (V% = number of repetitions x number of sets x number of exercises x % 1 repetition max) = 57.6%. Progression during the 12 week program will be attained by a 1RM test every 4 weeks.
Intervention Type
Behavioral
Intervention Name(s)
MDRT
Intervention Description
Following a warm-up of 10 min, subjects in the experimental group will undergo MDRT for two times per week, consisting of lower extremity exercises (leg press, knee extension, knee flexion). The exercise will be at 80% of 1RM concentric-only or 120% of 1RM eccentric-only in a 3:1 ratio. The volume % (V% = number of repetitions x number of sets x number of exercises x % 1 repetition max) = 57.6%. Progression during the 12 week program will be attained by a 1RM test every 4 weeks.
Primary Outcome Measure Information:
Title
Change in cognitive function on the Switching task (executive function)
Description
The switching task is a complex task where subjects need to switch (executive function) between a manikin task (visuospatial skill, attention and problem solving) and a mathematical computation task (mathematical computation skill, concentration and working memory).
Time Frame
Before first exercise bout, immediately after first exercise bout, 1 hour after the first exercise bout and after the 12 week intervention period
Secondary Outcome Measure Information:
Title
Change in cognitive function on the 2-Choice Reaction time (processing speed), Go/No-Go (inhibition) or 6 letter Memory Search (memory) test
Description
Cognitive functioning will be assessed with the Automated Neuropsychological Assessment Metrics 4 (ANAM4) cognitive test battery, testing several cognitive domains.
Time Frame
Before first exercise bout, immediately after first exercise bout, 1 hour after the first exercise bout and after the 12 week intervention period
Title
Changes in lactate levels
Description
Capillary lactate levels will be measured in the acute exercise test.
Time Frame
Before first exercise bout, immediately after first exercise bout, 1 hour after the first exercise bout
Title
Changes in blood serum levels of TNFalpha and syndecan
Description
We will use enzyme-linked immunosorbent assays (ELISAs) to measure acute changes in TNFalpha, and syndecan before and after the first exercise bout.
Time Frame
Before first exercise bout, immediately after first exercise bout, 1 hour after the first exercise bout
Title
Changes in blood plasma levels of BDNF
Description
We will use enzyme-linked immunosorbent assays (ELISAs) to measure acute and chronic changes in BDNF before and after the first exercise bout; and after 12 weeks intervention
Time Frame
Before first exercise bout, immediately after first exercise bout, 1 hour after the first exercise bout and after the 12 week intervention period
Title
Changes in blood serum levels of IGF-1, IL-6 and kynurenine
Description
We will use enzyme-linked immunosorbent assays (ELISAs) to measure chronic changes in IGF-1, IL-6 and kynurenine before and after 12 weeks intervention
Time Frame
Before and after the 12 week intervention period
Title
Changes in blood CK levels
Description
Blood CK levels will be measured in the MDRT group 48 hours after each eccentric-only training session to assess the muscle damaging effect/repeated bout effect.
Time Frame
Before first exercise bout and every 3 weeks for a total of 7 times 48 hours after the eccentric-only training session in the MDRT group.
Title
Changes in muscle contractile characteristics (with tensiomyography (TMG))
Description
Muscle involuntary contractile characteristics of the lower-limb muscles-the rectus femoris (RF), vastus medialis (VM), vastus lateralis (VL), biceps femoris (BF), semitendinosus (ST), tibialis anterior (TA), gastrocnemius medialis (GM) and gastrocnemius lateralis (GL)-will be recorded by measuring the response of these muscles to an induced electric stimulus (provoked by two self-adhesive electrodes) using TMG equipment on both the left and right lower extremities.
Time Frame
Before and after the 12 week intervention period
Title
Changes in BMI
Description
Weight and height will be combined to report BMI in kg/m^2
Time Frame
Before and after the 12 week intervention period
Title
Changes in body fat %
Description
body fat % will be measured using bio-impedance analysis (Tanita)
Time Frame
Before and after the 12 week intervention period
Title
Changes in SMI
Description
Skeletal muscle mass index (SMI, kg/m^2) will be measured using bio-impedance analysis (Tanita)
Time Frame
Before and after the 12 week intervention period
Title
Changes in fat free mass
Description
Fat free mass (kg) will be measured using bio-impedance analysis (Tanita)
Time Frame
Before and after the 12 week intervention period
Title
Changes in patellar tendon crossectional area
Description
Ultrasound will be used to assess the crossectional area (cm^2) of the pattella tendon
Time Frame
Before and after the 12 week intervention period
Title
Changes in patellar tendon stiffness
Description
While producing isometric knee extension force, ultrasound will be used to assess patellar tendon distension, which is a measure of tendon stiffness.
Time Frame
Before and after the 12 week intervention period
Title
Changes in quadriceps muscle fascicle length
Description
Ultrasound will be used to quantify muscle geometrical properties such as fascicle length (cm).
Time Frame
Before and after the 12 week intervention period
Title
Changes in quadriceps muscle fascicle angle
Description
Ultrasound will be used to quantify muscle geometrical properties such as fascicle angle (°).
Time Frame
Before and after the 12 week intervention period
Title
Changes in quadriceps muscle thickness
Description
Ultrasound will be used to quantify muscle geometrical properties such as quadriceps muscle thickness.
Time Frame
Before and after the 12 week intervention period
Title
Changes in quadriceps muscle cross-sectional area
Description
MRI will be used to measure muscle cross-sectional volume changes of the quadriceps muscles
Time Frame
Before and after the 12 week intervention period
Title
Changes in quadriceps muscle fiber type
Description
H-MRS (proton magnetic resonance spectroscopy) will be used to measure fiber type in the quadriceps muscle
Time Frame
Before and after the 12 week intervention period
Title
Changes in quadriceps muscle intramuscular fat
Description
H-MRS (proton magnetic resonance spectroscopy) will be used to measure intramuscular fat in the quadriceps muscle
Time Frame
Before and after the 12 week intervention period
Title
Changes in brain gray matter volume (with magnetic resonance imaging)
Description
MRI will be used to measure changes in gray matter volume using T1 images
Time Frame
Before and after the 12 week intervention period
Title
Changes in brain white matter volume (with magnetic resonance imaging)
Description
MRI will be used to measure changes in white matter integrity using DTI sequence
Time Frame
Before and after the 12 week intervention period
Title
Changes in brain neural integrity (with proton magnetic resonance spectroscopy)
Description
H-MRS will be used to measure changes in N-acetylaspartate levels in specific brain regions: right dorsolateral prefrontal cortex, left hippocampus and left primary sensorimotor cortex.
Time Frame
Before and after the 12 week intervention period
Title
Changes in brain neuroinflammation (with proton magnetic resonance spectroscopy)
Description
H-MRS will be used to measure changes in myo-inositol levels in specific brain regions: right dorsolateral prefrontal cortex, left hippocampus and left primary sensorimotor cortex.
Time Frame
Before and after the 12 week intervention period
Title
Changes in brain neuroplasticity marker (with proton magnetic resonance spectroscopy)
Description
H-MRS will be used to measure changes in Glx in specific brain regions: right dorsolateral prefrontal cortex, left hippocampus and left primary sensorimotor cortex.
Time Frame
Before and after the 12 week intervention period
Title
Changes in balance (with posturography on Kistler platform)
Description
Balance will be assessed in four different positions (two legs stance vs Romberg stance with eyes open vs closed) with or without a cognitive task to measure dual task effects.
Time Frame
Before and after the 12 week intervention period
Title
Changes in handgrip strength
Description
Handgrip strength will be measured using Jamar dynamometry
Time Frame
Before and after the 12 week intervention period
Title
Changes in maximal isometric strength (with Biodex)
Description
Knee extension/flexion maximal isometric strength (N) will be measured using Biodex.
Time Frame
Before and after the 12 week intervention period
Title
Changes in isokinetic peak torque (with Biodex)
Description
Knee extension/flexion isokinetic peak torque measurements will be done at 60°/s
Time Frame
Before and after the 12 week intervention period
Title
Changes in rate of force development (with Biodex)
Description
Rate of force development will be measured during maximal knee extension/flexion movement.
Time Frame
Before and after the 12 week intervention period
Title
Changes in physical performance (with the Fitness Fullerton Test battery for the Senior)
Description
Determination of motor control tasks relevant to daily life activities. A selection of tests, including the sit-to-stance test, timed up-and-go test, and other physical tests
Time Frame
Before and after the 12 week intervention period
Title
Changes in subjective quality of life (patient reported outcome questionnaires)
Description
Quality of life will be assessed using the World Health Organisation 100 (WHO 100) questionnaire
Time Frame
Before and after the 12 week intervention period
Title
Changes in nutrition (patient reported outcome questionnaires)
Description
We will use a selection of patient reported outcome measures to evaluate their nutrition (using the Actual nutrition registration questionnaire).
Time Frame
Before and after the 12 week intervention period
Title
Changes in subjective sleep quality (patient reported outcome questionnaires)
Description
We will use a selection of patient reported outcome measures to evaluate their quality of sleep (using the Stanford sleep quality scale).
Time Frame
Before and after the 12 week intervention period
Title
Changes in reported physical activity levels (patient reported outcome questionnaires)
Description
We will assess physical activity levels using the International Physical Activities Questionnaire (IPAQ)
Time Frame
Before and after the 12 week intervention period
10. Eligibility
Sex
Male
Minimum Age & Unit of Time
60 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
healthy male older adults
able to speak and read fluent Lithuanian
living in community during the study
Exclusion Criteria:
cognitive and neurological disorders (e.g. dementia, stroke, Parkinson, multiple sclerosis)
previous lower extremity injury
diabetes mellitus type I or II
no oncologic disease
no bone fractures in the previous year
deep vein thrombosis
cardiovascular disorders (e.g. congestive heart failure, angina pectoris, uncontrolled arrhythmia, history of myocardial infarction or coronary bypass grafting in the past year)
obesity (BMI >30kg/m²)
chronic fatigue, chronic headache, or chronic dizziness
ineligibility to MRI scanning (e.g. due to claustrofobia or metal implants)
The participants should not be engaged in any regular exercise programme during the previous 6 months (according to IPAQ), but able to perform 10 sit-ups
Any other consideration that interferes with the study aims and/or risk to the participant, at the discretion of the researcher
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Nerijus Masiulis, PhD
Phone
+37037302621
Email
nerijus.masiulis@lsu.lt
First Name & Middle Initial & Last Name or Official Title & Degree
Wouter Vints, MD
Phone
+31455282828
Email
w.vints@maastrichtuniversity.nl
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Nerijus Masiulis, PhD
Organizational Affiliation
Lithuanian Sports University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Lithuanian Sports University
City
Kaunas
ZIP/Postal Code
LT 44221
Country
Lithuania
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Diana Reklaitiene
Phone
+37037302621
Email
diana.reklaitiene@lsu.lt
12. IPD Sharing Statement
Plan to Share IPD
No
Learn more about this trial
Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and Muscle
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