Brown Fat Activation and Browning Efficiency Augmented by Chronic Cold and Nutraceuticals for Brown Adipose Tissue-mediated Effect Against Metabolic Syndrome (BEACON BEAMS Study)
Energy Expenditure, Obesity, Brown Adipose Tissue
About this trial
This is an interventional other trial for Energy Expenditure
Eligibility Criteria
Inclusion Criteria:
- Male or Female
- Chinese, Malay or Indian ethnicity
- Age between 21 to 50 years
- Able to give informed consent
- Body mass index (BMI) between 23 to 32 kg/m2
- Thyroid function test must be within the normal ranges
- Willing to avail yourself for the whole study and follow study procedures
EITHER deemed to have pre-metabolic syndrome when waist circumference is > 90 cm in men or > 80 cm in women, with none or up to one of the following condition:
- Triglyceride level ≥ 1.7 mmol/L
- HDL cholesterol ≤ 1.0 mmol/L in men, and ≤ 1.3 mmol/L in women
- Blood pressure ≥ 130/85 mmHg
- Fasting blood glucose of ≥ 6.1 mmol/L
OR deemed to have metabolic syndrome when three or more of the following conditions are present:
- Waist circumference > 90 cm in men and > 80 cm in women
- Triglyceride level ≥ 1.7 mmol/L
- HDL cholesterol ≤ 1.0 mmol/L in men, and ≤ 1.3 mmol/L in women
- Blood pressure ≥ 130/85 mmHg
- Fasting blood glucose of ≥ 6.1 mmol/L
Exclusion Criteria:
- Are pregnant or contemplating pregnancy (for female subjects)
- Partake in sports at the competitive and/or endurance levels
- Have known glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Have major chronic disease such as heart disease or cancer
- Take insulin or drugs known to affect glucose metabolism
- Intentionally restrict food intake
- Have major medical or surgical event requiring hospitalization within the preceding 3 months
- Have taken antibiotics for 3 months before the study period
- Are a smoker
- Are an overnight shift worker
- Have any known food allergy (eg. anaphylaxis to peanuts)
- Having active Tuberculosis (TB) or currently receiving treatment for TB
- Have any known Chronic Infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)
- Are a member of the research team or their immediate family members. Immediate family member is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.
- Enrolled in a concurrent research study judged not to be scientifically or medically compatible with the study of the CNRC
- Have poor veins impeding venous access
- Have any history of severe vasovagal syncope (blackouts or near faints) following blood draws
- History of surgery with metallic clips, staples or stents
- Presence of cardiac pacemaker or other foreign body in any part of the body
- History of claustrophobia particularly in a MRI scanner
Sites / Locations
- Singapore Institute of Clinical SciencesRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Cold Stimulation (CS)
Browning Nutraceutical (BN)
Cold Stimulation and Browning Nutraceutical (CSBN)
Subjects will undergo a mild cold stimulation of about 14 degrees Celsius by wearing a cooling vest for approximately an hour daily for the next 12 weeks or 3 months.
Subjects will consume 2000mg of curcumin daily for the next 12 weeks or 3 months.
Subjects will undergo a mild cold stimulation of about 14 degrees Celsius by wearing a cooling vest for approximately an hour and consume 2000mg of curcumin daily for the next 12 weeks or 3 months.