Can High-flow Nasal Oxygenation Improve Oxygen Saturation During Analgo-sedation in Obese Adults?
Noninvasive Ventilation, Respiratory Insufficiency, Obesity
About this trial
This is an interventional treatment trial for Noninvasive Ventilation focused on measuring "Noninvasive Ventilation"[Mesh], "Obesity"[Mesh], "Deep Sedation"[Mesh], "Hypoxia"[Mesh], "Adult"[Mesh], "Airway management"[Mesh], "Colonoscopy"[Mesh]
Eligibility Criteria
Inclusion Criteria:
- normal weight (18<BMI<30 kg/m2)
- obese patients (30<BMI<40 kg/m2)
- morbidly obese patients (BMI≥40 kg/m2)
- intravenous analgo-sedation
- elective colonoscopy
- colorectal tumors.
Exclusion Criteria:
- emergency colonoscopy
- diseases of peripheral blood vessels
- hematological diseases
- psychiatric diseases
- sideropenic anemia
- patients' refusal
- ongoing chemotherapy or irradiation
- propofol allergies
- fentanyl allergies.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Active Comparator
Active Comparator
Experimental
Experimental
Experimental
Normal weight 18<BMI<30 kg/m2 LFNO
Obese 30<BMI<40 kg/m2 LFNO
Morbidly obese BMI ≥40 kg/m2 LFNO
Normal weight 18<BMI<30 kg/m2 HFNO
Obese 30<BMI<40 kg/m2 HFNO
Morbidly obese BMI ≥40 kg/m2 HFNO
Low-flow nasal oxygenation (LFNO) O2 flow 5L/min, FiO2 40%
Low-flow nasal oxygenation (LFNO) O2 flow 5L/min, FiO2 40%
Low-flow nasal oxygenation (LFNO) O2 flow 5L/min, FiO2 40%
High-flow nasal oxygenation (HFNO) O2 flow 40L/min, FiO2 40%
High-flow nasal oxygenation (HFNO) O2 flow 40L/min, FiO2 40%
High-flow nasal oxygenation (HFNO) O2 flow 40L/min, FiO2 40%