Cardiovascular Effects of Exercise in Patients With Parkinson's Disease
Parkinson Disease, Orthostatic Hypotension
About this trial
This is an interventional treatment trial for Parkinson Disease focused on measuring Parkinson's Disease, Neurogenic orthostatic hypotension, Orthostatic intolerance, Exercise, Abdominal binder, Autonomic dysfunction, Dizziness, Physical Therapy, Blood pressure, Heart rate, Autonomic function testing, Neurology, Falls risk, Autonomic Nervous System, Autonomic reflex screening, Cerebral blood flow, Cerebral perfusion, Activities of Daily Living
Eligibility Criteria
Inclusion Criteria:
- Clinical diagnosis of Parkinson's Disease;
- Between stages 2 and 4 of Hoehn and Yahr classification of Parkinson's Disease;
- Male or female; and
- Age 40-90 years.
Exclusion Criteria:
- Therapy with anticholinergic, alpha- and beta-adrenergic antagonists or other medication, which could interfere with the regulation of blood pressure and heart rate. These medications are commonly used to treat conditions such as irregular heartbeats, high blood pressure, heart failure, urinary incontinence and other medical conditions (e.g. Alprazolam (Xanax), Amantadine (Symmetrel), Baclofen, Cimetidine, Codeine. Doxazosin, Prazosin, Atenolol (Tenormin), Bisoprolol (Zebeta, also sold as Ziac), Carvedilol (Coreg), Propranolol (Inderal, Inderal LA);
- Clinically significant coronary artery disease;
- Presence of nerve damage in the peripheral nervous system;
- Pregnant or breast feeding females; and
- The presence of failure of other organ systems or diseases that can affect autonomic function or the participant's ability to cooperate. These include dementia, specific tumors, heart failure, hypertension, renal or hepatic disease, severe anemia, alcoholism, hypothyroidism, surgical procedures where the nerves of the sympathetic nervous system have been cut, or cerebrovascular disease.
Sites / Locations
- University Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Abdominal Strengthening Exercise
Routine Care
All participants in this arm shall perform exercises for the strengthening of abdominal muscles for a period of three months in addition to the routine care provided to them for the management of Parkinson's Disease. The exercises are structured and need to be performed on a routine basis.
All participants in this group shall continue to obtain routine care for the management of Parkinson's Disease.