Cardiovascular Risk Reduction in Epilepsy
Epilepsy, Hypertension, Hyperlipidemia (E.G., Hypercholesterolemia)
About this trial
This is an interventional health services research trial for Epilepsy focused on measuring Epilepsy, Hyperlipidemia, Hypertension, Underserved
Eligibility Criteria
Inclusion Criteria Epilepsy defined as G40.0-G40.9 in the electronic medical record, or seizure disorder prescribed at least one antiseizure medication Age 40-79 (age range defined by ACC-ASCVD risk estimator+) Untreated HTN defined as at least two sitting BPs > 130/80 in the last year prior to enrollment or on enrollment Hyperlipidemia defined as LDL > 70 mg/dl with 10-year ACC-ASCVD score > 7.5% or total LDL > 190, or ASCVD recommendation to initiate lipid lowering agent Intellectual Disability, developmental disorder or autism recorded in the electronic medical record (ICD-10 codes F70-F79, F84) Exclusion Criteria: Stroke or cerebral hemorrhage < 1 year Documented poor compliance with treatment If intellectually disabled, if there is no caregiver to support or initiate therapy Pregnancy or person actively trying to become pregnant Blood Pressure > 180/110 Known secondary cause of hypertension that causes concern regarding safety of the protocol. Arm circumference too large or small to allow accurate blood pressure measurement with available devices Diabetes mellitus, Glomerulonephritis treated with or likely to be treated with immunosuppressive therapy eGFR < 20 ml/min /1.73m2 or end-stage renal disease (ESRD) Cardiovascular event, procedure or hospitalization for unstable angina within last 3 months Symptomatic heart failure within the past 6 months A medical condition likely to limit survival to less than 3 years or a malignancy other than non-melanoma skin cancer within the last 2 years Any factors judged by the clinic team to be likely to limit adherence to interventions. Failure to obtain informed consent from participant Any organ transplant
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Model 1-Neurologist Initiation of Treatment for Hypertension or Hyperlipidemia
Model 2-Usual Care
Neurologist Initiation of antihypertensive or treatment for hyperlipidemia
Usual care