Carvedilol Versus Metoprolol for the Prevention of Atrial Fibrillation After Off-Pump Coronary Bypass Surgery
Coronary Disease, Atrial Fibrillation
About this trial
This is an interventional prevention trial for Coronary Disease focused on measuring Adrenergic beta-Antagonists, Carvedilol, Metoprolol, Coronary Artery Bypass, Atrial Fibrillation
Eligibility Criteria
Inclusion criteria: Adult male or female patients are required to meet the following criteria: Aged 20 to 89 years Underwent isolated off-pump coronary artery bypass graft surgery Written informed consent Exclusion criteria: Patients with the following conditions will be excluded from the study: Pre- and intraoperative use of mechanical circulatory support devices, except an intra-aortic balloon pump Concomitant operations, such as aneurysmectomy or carotid endarterectomy Surgical approaches other than a median full sternotomy Acute myocardial infarction ≦3 days before enrollment in the trial Contraindication against treatment with β blockers Presence of preoperative chronic AF or flutter History of paroxysmal AF Presence of antidysrhythmic medication other than β blockers, calcium channel blockers, or digitalis A resting heart rate of less than 50 beats/min in the absence of medical therapy known to slow the sinus rate Endocrine disorders, such as pheochromocytoma, active hyperthyroidism, and untreated hypothyroidism Pregnant women and females with childbearing potential unless utilizing adequate contraception Preoperative need for a temporary or permanent pacemaker Non-interpretable electrocardiogram for P wave assessment Undergoing treatment for asthma or other chronic obstructive pulmonary disease Second- or third-degree atrioventricular block Sick sinus syndrome Uncontrolled heart failure Unstable insulin-dependent diabetes mellitus Steroid therapy requirement History of autoimmune diseases Active infectious diseases, including myocarditis or pericarditis Any other serious disease that could potentially complicate the management and follow-up protocols
Sites / Locations
- National Cardiovascular Center