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Cassia Cinnamon for Glucose Uptake in Young Women

Primary Purpose

Insulin Resistance, Impaired Glucose Tolerance, Prediabetes

Status

Completed

Phase

Not Applicable

Locations

United States

Study Type

Interventional

Intervention

Cassia cinnamon

50 minutes exercise

Cellulose Powder

About this trial

This is an interventional supportive care trial for Insulin Resistance focused on measuring Cassia, Cinnamon, Blood Glucose, Endurance exercise, Acute exercise, Overweight, Obesity, Women

Eligibility Criteria

18 Years - 30 Years (Adult)FemaleAccepts Healthy Volunteers

Inclusion Criteria:

Sedentary
BMI: 27-45
DXA body fat % greater than 30%
18-30 years of age
Healthy
From the Baylor University campus and surrounding community
Regular sleep habits

Exclusion Criteria:

Not regular users of any species of cinnamon
Not diagnosed with any metabolic disorder or chronic medical condition
Not taking prescription medications for 2 months before the study
Not taking ergogenic aids for 2 months before the study
Not taking oral contraceptives for 2 months before the study
No IUD placed for 2 months before the study

Sites / Locations

Baylor University Department of Health, Human Performance, and Recreation

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Active Comparator

Placebo Comparator

Arm Label

5g Cassia cinnamon

50 minutes endurnace exercise

5g Cellulose

Arm Description

Experimental treatment group

Endurance exercise treatment known to influence blood glucose

Placebo equivalent in weight and appearance to experimental treatment

Outcomes

Primary Outcome Measures

Blood Glucose

Secondary Outcome Measures

Serum Insulin

Full Information

NCT ID

NCT00951639

First Posted

August 3, 2009

Last Updated

March 3, 2022

Sponsor

Baylor University

1. Study Identification

Unique Protocol Identification Number

NCT00951639

Brief Title

Cassia Cinnamon for Glucose Uptake in Young Women

Official Title

Cassia Cinnamon and Acute Endurance Exercise for the Enhancement of Glucose Uptake in Healthy Young Women

Study Type

Interventional

2. Study Status

Record Verification Date

March 2022

Overall Recruitment Status

Completed

Study Start Date

February 2008 (undefined)

Primary Completion Date

May 2009 (Actual)

Study Completion Date

May 2009 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Baylor University

4. Oversight

Data Monitoring Committee

5. Study Description

Brief Summary

The purpose of this study was to compare the acute effects of 5g of Cassia cinnamon, 50 minutes of endurance exercise performed at 70% of the heart rate reserve (correlated to VO2max), and 5g of cellulose placebo on blood glucose, serum insulin and insulin sensitivity following an oral glucose tolerance test 3 hours after administration of each intervention.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Insulin Resistance, Impaired Glucose Tolerance, Prediabetes

Keywords

Cassia, Cinnamon, Blood Glucose, Endurance exercise, Acute exercise, Overweight, Obesity, Women

7. Study Design

Primary Purpose

Supportive Care

Study Phase

Not Applicable

Interventional Study Model

Crossover Assignment

Masking

ParticipantInvestigator

Allocation

Randomized

Enrollment

10 (Actual)

8. Arms, Groups, and Interventions

Arm Title

5g Cassia cinnamon

Arm Type

Experimental

Arm Description

Experimental treatment group

Arm Title

50 minutes endurnace exercise

Arm Type

Active Comparator

Arm Description

Endurance exercise treatment known to influence blood glucose

Arm Title

5g Cellulose

Arm Type

Placebo Comparator

Arm Description

Placebo equivalent in weight and appearance to experimental treatment

Intervention Type

Dietary Supplement

Intervention Name(s)

Cassia cinnamon

Other Intervention Name(s)

Brand: Nature's Bounty

Intervention Description

5g encapsulated ground bark administered once in experimental session

Intervention Type

Procedure

Intervention Name(s)

50 minutes exercise

Intervention Description

50 minutes treadmill endurance exercise at 70% of the heart rate reserve (correlated to VO2max)

Intervention Type

Dietary Supplement

Intervention Name(s)

Cellulose Powder

Intervention Description

5g encapsulated powder administered during placebo experimental session

Primary Outcome Measure Information:

Title

Blood Glucose

Time Frame

Baseline, 0, 30, 60, 90 and 120 minutes following OGTT

Secondary Outcome Measure Information:

Title

Serum Insulin

Time Frame

Baseline, 0, 30, 60, 90 and 120 minutes following OGTT

10. Eligibility

Sex

Female

Minimum Age & Unit of Time

18 Years

Maximum Age & Unit of Time

30 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Sedentary BMI: 27-45 DXA body fat % greater than 30% 18-30 years of age Healthy From the Baylor University campus and surrounding community Regular sleep habits Exclusion Criteria: Not regular users of any species of cinnamon Not diagnosed with any metabolic disorder or chronic medical condition Not taking prescription medications for 2 months before the study Not taking ergogenic aids for 2 months before the study Not taking oral contraceptives for 2 months before the study No IUD placed for 2 months before the study

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Darryn S Willoughby, Ph.D.

Organizational Affiliation

Baylor University

Official's Role

Study Chair

First Name & Middle Initial & Last Name & Degree

Jean L Gutierrez, Ph.D.

Organizational Affiliation

Baylor University

Official's Role

Principal Investigator

Facility Information:

Facility Name

Baylor University Department of Health, Human Performance, and Recreation

City

Waco

State/Province

Texas

ZIP/Postal Code

76798

Country

United States

12. IPD Sharing Statement

Citations:

PubMed Identifier

17556692

Citation

Hlebowicz J, Darwiche G, Bjorgell O, Almer LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr. 2007 Jun;85(6):1552-6. doi: 10.1093/ajcn/85.6.1552.

Results Reference

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PubMed Identifier

19158209

Citation

Hlebowicz J, Hlebowicz A, Lindstedt S, Bjorgell O, Hoglund P, Holst JJ, Darwiche G, Almer LO. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr. 2009 Mar;89(3):815-21. doi: 10.3945/ajcn.2008.26807. Epub 2009 Jan 21.

Results Reference

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PubMed Identifier

19159947

Citation

Solomon TP, Blannin AK. Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans. Eur J Appl Physiol. 2009 Apr;105(6):969-76. doi: 10.1007/s00421-009-0986-9. Epub 2009 Jan 22.

Results Reference

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PubMed Identifier

17924872

Citation

Solomon TP, Blannin AK. Effects of short-term cinnamon ingestion on in vivo glucose tolerance. Diabetes Obes Metab. 2007 Nov;9(6):895-901. doi: 10.1111/j.1463-1326.2006.00694.x.

Results Reference

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Cassia Cinnamon for Glucose Uptake in Young Women

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