Clinical Decision Support Tool for Vancomycin Dosing in Children
Gram-Positive Bacterial Infections, Vancomycin, Pharmacokinetics
About this trial
This is an interventional treatment trial for Gram-Positive Bacterial Infections focused on measuring computer decision support, gram positive bacterial infections, sepsis, vancomycin
Eligibility Criteria
Inclusion Criteria:
- Hospitalized infants and children from postmenstrual age of 38 weeks to age 19 years Requiring IV vancomycin, regardless of indication
- Parent or legally authorized representative is willing to provide permission and sign the informed consent document; subjects assent, when appropriate
- Hospitalized neonates, infants, children, adolescents who require, but have not been initiated on intravenous vancomycin therapy
Exclusion Criteria:
- Patients who had received vancomycin during previous 2 weeks
- Patients with end-stage renal disease, receiving hemodialysis or receiving continuous renal replacement therapy
- On oral or intraperitoneal vancomycin
- Receiving extracorporeal therapy, including extracorporeal membrane oxygenation, continuous renal replacement therapy, and extracorporeal liver support
- Will only receive a single dose of vancomycin
- Known to be pregnant
- Is brain dead or has suspected brain death
Sites / Locations
- University of Maryland Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Other
Intervention Group- Computer Decision Support Tool
Matched Historical Controls
Patients enrolled in the study will be started on IV vancomycin which will be dosed based on the LYV CDS tool, which will dose patients based on AUC24/MIC. Dosing will be adjusted based on vancomycin levels that will be drawn throughout the hospital stay. All patients prospectively enrolled into this study will be in the intervention group. Results will be compared to the retrospectively matched historical controls.
Match historical controls are patients that were on IV vancomycin with dose adjustments based on vancomycin trough levels. Patients in this study arm will be retrospective patients that will be matched with the intervention group.