Colchicine and CRP in Atrial Fibrillation and AF Ablation
Atrial Fibrillation
About this trial
This is an interventional treatment trial for Atrial Fibrillation focused on measuring atrial fibrillation, catheter ablation, colchicine, c reactive protein, CRP
Eligibility Criteria
Inclusion Criteria:
- Group 1: Persistent or chronic AF presenting for evaluation in cardiology offices. Diagnosis of AF will be made based on the 12 -lead surface ECG.
- Group 2: Paroxysmal AF scheduled to go AF ablation presenting to the electrophysiology laboratory for the procedure in sinus rhythm..
- Group 3:Chronic AF scheduled to go clinically indicated AF ablation, and presenting in the electrophysiology laboratory in atrial fibrillation .
Exclusion Criteria:
- Abnormal liver function with elevated enzymes> 1.5 times the normal.
- Abnormal kidney function with glomerular filtration rate < 50 ml/min
- Increased levels of creatine kinase or known myopathy
- Neutropenia
- Known GI disorders
- Women of childbearing age who have not had surgical sterilization and are not using oral contraceptives, or who's spouse has not had surgical sterilization will be excluded due to the length of the trial and the possibility that they could become pregnant after entry.
- Pregnant and lactating women
- Lactose intolerance
- Known sensitivity, allergy, or contraindication to colchicine use
Sites / Locations
- Mayo Clinic Florida
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Placebo Comparator
Active Comparator
Placebo Comparator
Active Comparator
Placebo Comparator
Chronic atrial fibrillation, colchicine
Chronic atrial fibrillation, placebo
Pre-ablation, sinus rhythm, colchicine
Pre-ablation, sinus rhythm, placebo
Pre-ablation, AF, colchicine
Pre-ablation, AF, placebo
Colchicine 0.6 mg PO BID. Subjects not undergoing ablation.
Matching placebo. Subjects not undergoing ablation.
Colchicine 0.6 mg PO BID. Subjects undergoing ablation.
Matching placebo. Subjects undergoing ablation.
Colchicine 0.6 mg PO BID. Subjects undergoing ablation.
Matching placebo. Subjects undergoing ablation.