Conduction System Pacing Versus Biventricular Pacing After Atrioventricular Node Ablation (CONDUCT-AF)
Heart Failure, Tachycardia-induced Cardiomyopathy, Atrial Fibrillation
About this trial
This is an interventional treatment trial for Heart Failure focused on measuring Heart failure, Atrial fibrillation, Conduction system pacing, His bundle pacing, Left bundle branch pacing, Biventricular pacing, Atrioventricular node ablation
Eligibility Criteria
Inclusion Criteria:
- Symptomatic permanent atrial fibrillation, refractory to drug therapy or failed catheter ablation
- Left ventricular ejection fraction <50%
- Narrow intrinsic QRS ≤ 120 ms
- NT-proBNP > 600 ng/L
- Patient has provided written informed consent
- Age between 18 years and 85 years
Exclusion Criteria:
- Pre-existing permanent pacemaker, implantable cardioverter-defibrillator or cardiac resynchronization device. Patients who had devices implanted that had <5% of paced beats (i.e., backup pacing) can be enrolled.
- Life expectancy less than 12 months
- Severe concomitant non-cardiac disease
- Pregnancy
- Recent (<3 months) myocardial infarction, percutaneous or surgical myocardial revascularization
- Significant heart valve disease (severe insufficiency or stenosis)
- Contraindication for oral anticoagulation
- Mechanical tricuspid valve replacement
- Unwillingness to participate or lack of availability for follow-up
Sites / Locations
- University Hospital Graz - Divison of CardiologyRecruiting
- Hospital Oost-Limburg (Hartzentrum Genk)Recruiting
- Acibadem City Clinic Tokuda Hospital - Department of Invasive ElectrophysiologyRecruiting
- Clinical Hospital Center RijekaRecruiting
- University Hospital of SplitRecruiting
- University Hospital Centre ZagrebRecruiting
- County Clinical emergency hospital of Brasov - Department of Interventional CardiologyRecruiting
- University Medical Centre Ljubljana - Department of cardiologyRecruiting
- University Medical Centre Ljubljana - Department of cardiovascular surgeryRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Biventricular pacing + AV node ablation
Conduction system pacing + AV node ablation
Implantation of biventricular pacemaker with or without defibrillator lead placement followed by AV node ablation. Optimal guidelines-based heart failure treatment.
Implantation of permanent pacemaker with conduction system pacing (preferably left bundle branch) with or without defibrillator lead placement followed by AV node ablation. Optimal guidelines-based heart failure treatment.