Cycling Deep Brain Stimulation on Parkinson's Disease Gait (DBS)
Parkinson Disease
About this trial
This is an interventional treatment trial for Parkinson Disease
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of idiopathic Parkinson's disease
- Currently receiving Deep Brain Stimulation as a Parkinson's disease treatment
- Hoehn & Yahr stage between 2-4 during off-medication
- Underlying gait disorders despite optimal medical and stimulation treatment: score over or equal to 1 in the subitem 2.12 of the MDS-UPDRS scale
- Willingness to comply with all study procedures
Exclusion Criteria:
- Active moderate/severe psychiatric condition
- Active infection or other uncontrolled moderate/grave comorbidities
- Treatment with experimental drug
- Pregnancy or breast-feeding
Sites / Locations
- Hospital das Clínicas da Faculdade de Medicina da USPRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
No Intervention
Experimental
Experimental
Experimental
Regular Continuous High Frequency
Cycling High Frequency
Continuous Low Frequency
Cycling Low Frequency
Patient remains 2 weeks in the currently chosen stimulation protocol.
Patient is stimulated with the same polarity, voltage/current, pulse width and frequency as the currently chosen stimulation protocol, but with cycling stimulation: 40sec On - 02 sec OFF
Patient is stimulated with the same polarity and pulse width as the currently chosen stimulation protocol, but with low frequency (80Hz). Voltage/current will be adjusted to maintain TEED similar to that on the regular stimulation protocol.
Patient is stimulated with the same polarity and pulse width as the currently chosen stimulation protocol, but with low frequency (80Hz) and cycling stimulation: 40sec On - 02 sec OFF. Voltage/current will be adjusted to maintain TEED similar to that on the regular stimulation protocol.