Dietetic and Hygiene Measures in Metabolic Neuropathies: the Neurodiet Study

Metabolic disorders such as diabetes mellitus, glucose intolerance and possibly metabolic syndrome can induce a peripheral neuropathy. To investigate the effect of physical training and diet education on neuropathic symptoms and neurophysiological parameters of patients with metabolic neuropathies.

Metabolic disorder such as diabetes mellitus, glucose intolerance and possibly metabolic syndrome can induce a peripheral neuropathy. The objectives of the present study are to investigate: the effect of physical training and diet education on neuropathic symptoms and neurophysiological parameters the best coaching modality of education. This will be a prospective single blind study (blinded evaluator). Patients will be randomly assigned in two groups. The first group will have a one-day therapeutic education program followed by a 5-minutes phone call every week for 3 months. The second group will have the same one-day therapeutic education program that will be followed by an unique one-hour phone call. During the one-day therapeutic education program and the phone calls, hygienic rules (ie physical activities) and dietetic regimen advices will be given to patients. Evaluation will be done at 3 months.

Therapeutic education about hygienic-dietetic measures followed by a 5 minutes phone call per week during 3 months

Change from Baseline in NTSS6 score at 3 months (Bastyr EJ, 3rd, Price KL, Bril V. Development and validity testing of the neuropathy total symptom score-6: questionnaire for the study of sensory symptoms of diabetic peripheral neuropathy. Clin Ther. 2005 Aug;27(8):1278-94)

change from baseline of sensory nerve action potential and sensory and motor nerve velocity at 3 months

Inclusion Criteria: Clinical and neurophysiologic neuropathy (clinical signs of neuropathy and at least two low sensory nerve action potential (superficial peroneal and sural nerves)) Metabolic disorder: Glucose disorder (diabetes mellitus or glucose intolerance) or metabolic syndrome Clinical signs for less than 2 years No therapeutic modification in the last 3 months Possibility to delay any drug modification during 3 months Exclusion Criteria: Non metabolic neuropathy Serious diabetic complication Renal failure (creatinine clearance<60ml/min) Sensory neuronopathy Contra-indication to physical activity Type 1 diabetes mellitus No written consent