Digital Variance Angiography for Contrast Media Dose Reduction in Carotid Artery Stenting
Carotid Artery Diseases
About this trial
This is an interventional other trial for Carotid Artery Diseases focused on measuring Radiocontrast media reduction, X-ray angiography, Digital Variance Angiography, Digital Subtraction Angiography, carotid artery stenting, Kinepict
Eligibility Criteria
Inclusion Criteria:
- Age > 18 y
- Carotid stenosis defined as:
Stenosis ≥70% by computer tomography angiography (NASCET criteria); OR by duplex-ultrasound with ≥70% stenosis defined by a peak systolic velocity of at least 230 cm/s
- Carotid stenosis is treatable with CAS
Exclusion Criteria:
- History of stroke or TIA ipsilateral to the stenosis within 30 days of randomization
- Acute myocardial infarction
- Severe chronic kidney disease: GFR>30ml/min/m2
- Severe heart failure: NYHA IV
- Severe liver failure: Child-Pugh 3
- Iodine contrast allergy
- Coagulopathy
- Hematological bleeding disorders
Sites / Locations
- Semmelweis University, Heart and Vascular CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Group A: Reduced contrast media dose group
Group B: Standard contrast media dose group
Reduced contrast media protocol: extracranial carotid artery intervention (2-4 fps according to the institutional protocol). Contrast administration with an automatic contrast injector: angiographic image acquisitions will be performed with 6 ml of 50% contrast media (3 ml iodined contrast media, 3 ml physiologic saline) with a 3 ml/s flow rate. DSA and DVA images will be calculated; DVA images will be used for diagnosis and interventions.
Standard contrast media protocol: extracranial carotid artery intervention (2-4 fps according to the institutional protocol). Contrast administration with an automatic contrast injector: angiographic image acquisitions will be performed with 6 ml iodined contrast media with a 3 ml/s flow rate. DSA and DVA images will be calculated; DSA images will be used for diagnosis and interventions.