Effect of Dietary Flavonoids on Intestinal Microbiota, Intestinal Inflammation and Metabolic Syndrome
Metabolic Syndrome X, Inflammation
About this trial
This is an interventional basic science trial for Metabolic Syndrome X focused on measuring flavonoids, insulin resistance, plasma lipids, intestinal microbiome, intestinal inflammation, subclinical inflammation
Eligibility Criteria
Inclusion Criteria:
- BMI between 25 and 35 kg/m2
Exclusion Criteria:
- Documented presence of atherosclerotic disease;
- Diabetes mellitus
- Uncontrolled hypertension
- Renal, hepatic, endocrine, gastrointestinal or other systemic disease
- For women, pregnancy, breast feeding or postpartum < 6 months
- History of drug or alcohol abuse
- History of depression or mental illness requiring hospitalization within the last 12 months
- Use of antibiotics within the last 6 months
- Multiple food allergies or significant food preferences or restrictions that would interfere with diet adherence
- Chronic use of over-the-counter medication which would interfere with study endpoints including NSAIDS, laxatives and antacids
- Lifestyle or schedule incompatible with the study protocol
- Other medical, psychiatric, or behavioral conditions that in the view of the principal investigator may present a safety hazard to the participant or interfere with study participation or the ability to follow the intervention protocol.
Sites / Locations
- Utah State University, Center for Human Nutrition Studies
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Low Flavonoids then High Flavonoids
High Flavonoids then Low Flavonoids
Participants receive a prepared diet with Low Dietary Flavonoids (10 mg of flavonoids/1000 Kcals) for six weeks. After a minimum washout period of 2 weeks, participants receive a prepared diet with High Dietary Flavonoids (340 mg of flavonoids/1000 Kcals) for six weeks.
Participants receive a prepared diet with High Dietary Flavonoids (340 mg of flavonoids/1000 Kcals) for six weeks. After a minimum washout period of 2 weeks, participants receive a prepared diet with Low Dietary Flavonoids (10 mg of flavonoids/1000 Kcals) for six weeks.