Effects of Deep Brain Stimulation on Motor, Mood, and Cognitive Symptoms in Parkinson's Disease
Parkinson Disease
About this trial
This is an interventional treatment trial for Parkinson Disease focused on measuring Parkinson's disease, Parkinson disease, PD, deep brain stimulation, DBS, subthalamic nucleus, STN, globus pallidus interna, GPi, mood, motor symptoms, cognition, emotion, memory, attention, tremor, rigidity, bradykinesia
Eligibility Criteria
Inclusion Criteria: Intractable, disabling PD with motor fluctuations, dyskinesias, or freezing episodes Age between 30-75 years Unsatisfactory clinical response to maximal medical management (with trials of both higher and lower doses of anti-Parkinsonian drugs) A stable and optimal medical regimen of anti-Parkinsonian drug therapy for at least three months prior to surgery Patients must be right-handed to be included in the study since mood and cognition are being analyzed and right hemisphere dominant patients could confound the results. Exclusion Criteria: Clinically significant medical disease that would increase risk of developing pre- or postoperative complications (e.g., significant cardiac or pulmonary disease, uncontrolled hypertension) Evidence of secondary or atypical parkinsonism as suggested by the presence of any of the following: 1) history of stroke(s), 2) exposure to toxins or neuroleptics, 3) history of encephalitis, 4) neurological signs of upper motor neuron disease, cerebellar involvement, supranuclear gaze palsy, or significant orthostatic hypotension MRI scan with significant evidence of brain atrophy or other abnormalities (e.g., lacunar infarcts or iron deposits in the putamen) The Mattis Dementia Rating Scale will be used to assess the level of intellectual function and patients will be excluded with scores reflecting clinical dementia A major psychiatric disorder on the Structured Clinical Interview for DSM-IV (SCID-IV).
Sites / Locations
- University of Florida College of Medicine, Department of Neurology, McKnight Brain Institute, 100 South Newell Drive, L-3 100
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
No Intervention
STN DBS
GPI DBS
no DBS
Patients who underwent deep brain stimulation (DBS) of the subthalamic nucleus (STN) to treat Parkinson's disease (PD)
Patients who underwent deep brain stimulation (DBS) of the globus pallidus interna (GPi) to treat Parkinson's disease (PD)
non-DBS PD patient control group