Efficacy of Different Ablation Strategies for Controlling Atrial Fibrillation (RASTA)
Atrial Fibrillation
About this trial
This is an interventional treatment trial for Atrial Fibrillation focused on measuring Atrial Fibrillation, A-Fib, AF, Persistent, Permanent, Pulmonary Vein Isolation, Ablation
Eligibility Criteria
Inclusion Criteria:
- All patients of age ≥ 30 years, undergoing their first ablation procedure that meet ACC / AHA defined criteria for persistent or permanent AF will be eligible to participate in the study. This includes patients with a history of AF episodes lasting at least 7 days or requiring at least 2 cardioversions.
Exclusion Criteria:
- Patients with paroxysmal AF (self-terminating episodes lasting < 7 day)
- Patients who have had a previous AF ablation procedure
- Pregnancy
- Failure to obtain informed consent
- Less than 30 years old
Sites / Locations
- University of Pennsylvania Health System
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Active Comparator
Group 1
Group 2
Group 3
Pulmonary vein isolation (PVI) combined with ablation of documented non-PV triggers of atrial fibrillation --- (sites away from the pulmonary veins where consistent abnormal impulses that can trigger AF are identified during the procedure)
PVI combined with ablation at documented sites of non-PV triggers, PLUS ablation at sites where non-PV triggers are commonly found
PVI combined with ablation at documented sites of non-PV triggers and ablation at sites in the left atrium that demonstrate disorganized electrical impulses called complex fractionated electrograms (CFE).