Electrophysiologically Guided PAcing Site Selection Study (EPASS)
Sinus Arrhythmia, Atrial Fibrillation
About this trial
This is an interventional prevention trial for Sinus Arrhythmia focused on measuring atrial fibrillation, interatrial septum, atrial pacing, symptomatic sinus node dysfunction,, pacemaker indication class I
Eligibility Criteria
Inclusion Criteria: Symptomatic sinus node dysfunction More than 18 years old Signed informed consent Exclusion Criteria: Less than 18 years old Pregnancy Anamnestic transient ischemic attack (TIA) or stroke Neoplastic or any other severe disease reducing life expectancy Heart surgery in the last 3 months Left atrial diameter > 55mm, determined in the parasternal long-axis view (during either sinus rhythm or atrial fibrillation) Participation in other studies
Sites / Locations
- Azienda Ospedaliera di Desenzano del Garda
- Divisione di Cardiologia
- Divisione di Cardiologia - CRN
- Divisione di Cardiologia - Ospedale Cisanello
- Divisione di Cardiologia - Ospedale San Pietro Igneo
- Divisione di Cardiologia - Ospedale Molinette
- Divisione di Cardiologia - Ospedale Civile ULSS 13
- Divisione di Cardiologia - Presidi Ospedalieri Riuniti
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Active Comparator
Active Comparator
1. IAS pacing - study group
2. IAS pacing-control group
3. RAA Pacing - study group
4. RAA Pacing - control group
Patients were first submitted to electrophysiological study to assess Delta CTos > or < 50 ms. Then they were randomized to interatrial septum pacing od right atrial appendage. This arm (1) includes patients with Delta CTos >50 ms and randomized IAS pacing. IAS Pacing -Study Group: Patients with Delta CTos >50 ms (study group) at the electrophysiologic study and randomized Interatrial Septum Pacing
(Delta CTos<50ms) Patients were first submitted to electrophysiological study to assess Delta CTos > or < 50 ms. Then they were randomized to interatrial septum pacing od right atrial appendage. This arm (2) includes patients with Delta CTos <50 ms and randomized IAS pacing. IAS Pacing -Control Group: Patients with Delta CTos <50 ms (control group) at the electrophysiologic study and randomized Interatrial Septum Pacing
Patients were first submitted to electrophysiological study to assess Delta CTos > or < 50 ms. Then they were randomized to interatrial septum pacing od right atrial appendage. This arm (3) includes patients with Delta CTos >50 ms and randomized Right Atrial Appendage pacing. RAA Pacing -Study Group: Patients with Delta CTos >50 ms (study group) at the electrophysiologic study and randomized Right Atrial Appendage pacing
Patients were first submitted to electrophysiological study to assess Delta CTos > or < 50 ms. Then they were randomized to interatrial septum pacing od right atrial appendage. This arm (4) includes patients with Delta CTos <50 ms and randomized Right Atrial Appendage pacing. RAA Pacing -Control Group: Patients with Delta CTos <50 ms (control group) at the electrophysiologic study and randomized Right Atrial Appendage pacing