Evaluation of Age- and Alzheimer's Disease-Related Memory Disorder

INCLUSION CRITERIA: Patients will be referred through the GPB screening protocol 95-M-0096: Subjects will include: AD patients, diagnosis based on DSM-IV (APA Press, 1994) criteria, Individuals over the age of 50 who are "at-risk" for AD on the basis of having first-degree relatives with AD and who tested within the normal range on a battery of cognitive tests at the time of initial inclusion, Individuals with mild cognitive impairment (memory problems significant enough to concern the individual or members of the individual's family who do not meet the criteria for AD), Control subjects, individuals without a positive family history of dementia in their first degree relatives and who test within the normal range on the battery of cognitive tests. As part of this screening process subjects who medical histories significant for any medical condition that would make it unsafe to perform MRI scans will be excluded. EXLCUSION CRITERIA: The same exclusion criteria used in those protocols for structural MRI and delineated under Hazards and Precautions would again be used. All subjects participating in functional MRI scans will be required to be off prescription medications which could effect these scans, such as medications with anticholinergic effects, for two weeks-to one month prior to PET scan, and off psychotropic medication for one month. Withdrawal from psychotropic medications for purposes of participation in this protocol would only be considered for individuals already involved in the Longitudinal Study Protocol 95-M-0096. Subjects will be cautioned not to consume alcohol, marijuana, or psychotropic drugs while on the study, nor to smoke, use caffeinated beverages, or take over-the counter medications such as cold medications (i.e.: benadryl, sudafed) for at least 12 hours prior to the functional MRI scans. Pregnancy test will be conducted prior to MRI scans on women of childbearing age.