Evaluation of Liraglutide 3.0mg in Patients With Poor Weight-loss and a Suboptimal Glucagon-like Peptide-1 Response (BARIOPTIMISE)
Obesity

About this trial
This is an interventional treatment trial for Obesity focused on measuring obesity, GLP-1, liraglutide, diabetes, bariatric surgery
Eligibility Criteria
Inclusion Criteria:
- Patients, 1 year or more after primary RYGB or primary SG, with poor weight-loss (<20% WL) that is not caused by either a surgical or psychological problem.
- Adults, 18-64 years inclusive.
- Suboptimal nutrient-stimulated GLP-1 response assessed by a meal test. Suboptimal active GLP-1 response is defined as a ≤2-fold increase in active GLP-1 circulating levels between time 0 and time 30 minutes.
- Females of childbearing potential and males must be willing to use an effective method of contraception (hormonal or barrier method of birth control, abstinence) from the time consent is signed until 6 weeks after treatment discontinuation.
- Females of childbearing potential must have a negative pregnancy test within 7 days prior to being registered for trial treatment. NOTE: Subjects are considered not of child bearing potential if they are surgically sterile (i.e. they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal.
- ≤5 % variation in body weight over preceding 3 months.
- Fluent in English and able to understand and complete questionnaires.
- Willing and able to provide written informed consent and comply with the trial protocol.
Exclusion Criteria:
- Had a surgical procedure other than gastric bypass and sleeve gastrectomy.
- Pregnant or lactating mothers.
- Participation in other clinical intervention trial.
- Lifetime history of suicidal behaviour or severe depression assessed by direct questioning.
- Clinically significant medical abnormalities (e.g., unstable hypertension, clinically significant ECG abnormalities, liver cirrhosis, AST or ALT > 3x the upper normal limit).
- Heart rate ≥ 100 beats/minute at screening on two separate measurements.
- Uncontrolled hypertension (systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 100 mmHg).
- Renal impairment (estimated glomerular infiltration rate (eGFR <30 ml/min 1.73 m2)
- Known or suspected hypersensitivity to liraglutide 3.0 mg and placebo or any of the excipients involved in their formulation.
- Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.
- Personal history of pancreatitis.
- Uncontrolled hypothyroidism or hyperthyroidism.
- History of stroke, unstable angina, acute coronary syndrome, congestive heart failure New York Heart Association class III-IV within the preceding 12 months.
- History of arrhythmias.
- Inflammatory bowel disease.
- Diabetic gastroparesis.
- Concomitant GLP-1 receptor agonist usage.
- Concomitant usage of medications that cause weight gain or weight loss.
- Concomitant usage of DPPIV-inhibitors.
- Insulin usage.
Sites / Locations
- UCLH
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Treatment
Control
Daily subcutaneous injection of liraglutide 3.0 mg Study dosing of liraglutide: Week 1: 0.6 mg once daily Week 2: 1.2 mg once daily Week 3: 1.8 mg once daily Week 4: 2.4 mg once daily Week 5-24: 3.0 mg once daily In addition to the daily injection of liraglutide/placebo, participants in both groups will be advised to cut down approximately 500 calories from their usual food intake and to achieve a minimum of 150 minutes per week of physical activity.
Daily subcutaneous injection of placebo; the same dosage regimen as treatment to be followed. In addition to the daily injection of liraglutide/placebo, participants in both groups will be advised to cut down approximately 500 calories from their usual food intake and to achieve a minimum of 150 minutes per week of physical activity.