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Exercise and Branched Chain Amino Acids (BCAA)Requirements in Older Men

Primary Purpose

Sarcopenia

Status
Suspended
Phase
Not Applicable
Locations
Canada
Study Type
Interventional
Intervention
Branched chain amino acid
Strength training
Sponsored by
University of Western Ontario, Canada
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Sarcopenia focused on measuring branched chain amino acid requirement, older men, strength training, sarcopenia

Eligibility Criteria

55 Years - 65 Years (Adult, Older Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

  • Recreationally active (~2-3 h/wk of physical activity) healthy older men (55-65 y)
  • A minimum of 4 month weight training experience

Exclusion Criteria:

  • Have symptoms or take medication for respiratory disease
  • Have symptoms or take medication for cardiovascular disease
  • Have symptoms or take medication for metabolic disease
  • Have symptoms or take mediation for neuromuscular disease
  • Use heart rate or blood pressure medications
  • Use any medications with side effects of dizziness, lack of motor control, or slowed reaction time
  • Have an excessive alcohol intake (more than 2 drinks per day)
  • Have any cardiovascular or neuromuscular limitations to exercise
  • Are allergic to milk or milk products
  • Use anabolic steroids or performance enhancing drugs

Sites / Locations

  • Exercise Nutrition Research Laboratory

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Active Comparator

Arm Label

Branched chain amino acid

Weight training

Arm Description

Branched chain amino acid as food supplement

Strength training will include a split-training program using all major muscle groups of the body on a three day "on", one day "off" protocol. Muscle areas targeted on each training day will be as follows: Day1: chest, shoulder, triceps; Day2: back, biceps; Day3: legs and calfs; Day4: will be a rest day. On Day5: this cycle will begin again. A combination of free weights and machines will be used for each training day. Progressive overload protocol will be applied where the load used by every participant will be adjusted bi-weekly based on their 70% of 1RM (repetition maximum). Instruction will be provided for all exercises and professional trainers will oversee all training sessions.

Outcomes

Primary Outcome Measures

Required Branched chain amino acid of older strength trained men
Branched chain amino acid requirement will be measured in 55-65 years old strength trained men using indicator amino acid oxidation method

Secondary Outcome Measures

Muscle size
cross-sectional measure of muscle size will be measured in all participants using standard procedures of magenetic resonance imaging

Full Information

First Posted
August 26, 2013
Last Updated
January 9, 2016
Sponsor
University of Western Ontario, Canada
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1. Study Identification

Unique Protocol Identification Number
NCT01931722
Brief Title
Exercise and Branched Chain Amino Acids (BCAA)Requirements in Older Men
Official Title
Can Branched Chained Amino Acid Supplementation Combined With Strength-Training Minimize Sarcopenia in Older Men?
Study Type
Interventional

2. Study Status

Record Verification Date
January 2016
Overall Recruitment Status
Suspended
Why Stopped
not able to find enough participants for this study
Study Start Date
January 2016 (undefined)
Primary Completion Date
December 2016 (Anticipated)
Study Completion Date
December 2016 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Western Ontario, Canada

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
Likely, branched chain amino acid (BCAA) requirements are increased in older strength-trained (ST) individuals. If so, supplementation in this group will maximize muscle protein synthesis (MPS) and minimize loss of muscle with age (sarcopenia).
Detailed Description
We hypothesize that the dietary requirement for the branched chain amino acids (BCAA) in an older strength-trained (ST) population will be greater than the current recommendation (RDA). If so, a greater intake of BCAA together with ST is necessary if one aims to maximize muscle protein synthesis (MPS). Currently, the BCAA requirement in the ST older population (55-65 y) is unknown. This is critical information especially given the value of ST for overall health.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Sarcopenia
Keywords
branched chain amino acid requirement, older men, strength training, sarcopenia

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
6 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Branched chain amino acid
Arm Type
Active Comparator
Arm Description
Branched chain amino acid as food supplement
Arm Title
Weight training
Arm Type
Active Comparator
Arm Description
Strength training will include a split-training program using all major muscle groups of the body on a three day "on", one day "off" protocol. Muscle areas targeted on each training day will be as follows: Day1: chest, shoulder, triceps; Day2: back, biceps; Day3: legs and calfs; Day4: will be a rest day. On Day5: this cycle will begin again. A combination of free weights and machines will be used for each training day. Progressive overload protocol will be applied where the load used by every participant will be adjusted bi-weekly based on their 70% of 1RM (repetition maximum). Instruction will be provided for all exercises and professional trainers will oversee all training sessions.
Intervention Type
Dietary Supplement
Intervention Name(s)
Branched chain amino acid
Other Intervention Name(s)
Ajinomoto branched chain amino acids
Intervention Description
seven graded intakes of a BCAA (branched chain amino acid) mixture from 50 to 350 mg.kg-1.d-1 will be used to measure BCAA requirement
Intervention Type
Behavioral
Intervention Name(s)
Strength training
Other Intervention Name(s)
weight training
Intervention Description
Strength training will include a split-training program using all major muscle groups of the body on a three day "on", one day "off" protocol. Muscle areas targeted on each training day will be as follows: Day1: chest, shoulder, triceps; Day2: back, biceps; Day3: legs and calfs; Day4: will be a rest day. On Day5: this cycle will begin again. A combination of free weights and machines will be used for each training day. Progressive overload protocol will be applied where the load used by every participant will be adjusted bi-weekly based on their 70% of 1 repetition maximum (maximum weight that can be lifted only one time). Instruction will be provided for all exercises and professional trainers will oversee all training sessions.
Primary Outcome Measure Information:
Title
Required Branched chain amino acid of older strength trained men
Description
Branched chain amino acid requirement will be measured in 55-65 years old strength trained men using indicator amino acid oxidation method
Time Frame
12 months
Secondary Outcome Measure Information:
Title
Muscle size
Description
cross-sectional measure of muscle size will be measured in all participants using standard procedures of magenetic resonance imaging
Time Frame
12 months

10. Eligibility

Sex
Male
Minimum Age & Unit of Time
55 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Recreationally active (~2-3 h/wk of physical activity) healthy older men (55-65 y) A minimum of 4 month weight training experience Exclusion Criteria: Have symptoms or take medication for respiratory disease Have symptoms or take medication for cardiovascular disease Have symptoms or take medication for metabolic disease Have symptoms or take mediation for neuromuscular disease Use heart rate or blood pressure medications Use any medications with side effects of dizziness, lack of motor control, or slowed reaction time Have an excessive alcohol intake (more than 2 drinks per day) Have any cardiovascular or neuromuscular limitations to exercise Are allergic to milk or milk products Use anabolic steroids or performance enhancing drugs
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Peter Lemon, PhD
Organizational Affiliation
The University of Western Ontario
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Arash Bandegan, MSc.
Organizational Affiliation
The University of Western Ontario
Official's Role
Study Director
Facility Information:
Facility Name
Exercise Nutrition Research Laboratory
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5B9
Country
Canada

12. IPD Sharing Statement

Citations:
PubMed Identifier
12730426
Citation
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Results Reference
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Citation
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PubMed Identifier
12626690
Citation
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Exercise and Branched Chain Amino Acids (BCAA)Requirements in Older Men

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