Exercise and Nutrition for Healthy AgeiNg (ENHANce)
Sarcopenia
About this trial
This is an interventional treatment trial for Sarcopenia focused on measuring Sarcopenia, Nutrition, Protein, Vitamin D, Exercise, Older people, Frailty
Eligibility Criteria
Inclusion Criteria:
- Male or female persons with (pre)sarcopenia according to the European Working Group on Sarcopenia in Older People (EWGSOP): reduced muscle mass without (presarcopenia) or with (sarcopenia) reduced walking speed (≤ 0.8m/s) or muscle strength OR probable, confirmed or severe sarcopenia according to EWGSOP 2.
- 65 years or older;
- Community-dwelling elderly or assisted living;
In case of one or more positive answer(s) on the health screen for exercise, subjects need approval of their general practitioner to participate in this randomized controlled trial (RCT).
- Uncontrolled or unstable health problems
- Uncontrolled pain or feeling unwell the day of the exercise
- Recently diagnosed cardiovascular events
- systolic blood pressure (SBP) ≥ 180 mmHg and/or diastolic blood pressure (DBP) ≥ 100 mmHg
- Resting tachycardia > 100 bpm
- Uncontrolled atrial or ventricular arrhythmias
- Unstable or acute heart failure
- Lasting, increased pain following a previous session
- Suspected acute injury
- Recent injurious fall without medical assessment
- Severe breathlessness or dizziness
- Uncontrolled pulmonary problems
- Rheumatoid arthritis flare up or acute systemic illness/infection
- Unexplained lethargy
Exclusion Criteria:
- Impairments/diseases that impose problems to participation in the study;
- Allergy to milk or soy or peanut;
- Mini-Mental State Examination (MMSE) < 21;
- Terminal illness (prognosis < 6 months);
- Persons who followed a physical training program in the last 6 months (twice or more/week);
- Persons with a daily intake of > 1.5 g protein/kg body weight (BW)/day;
- Diagnosis of severe kidney disease (GFR < 30 ml/min) or diabetes mellitus;
- Unable to communicate in Dutch, English or French.
Sites / Locations
- Gerontology and Geriatrics, Department of Public Health and Primary Care, KU LeuvenRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Experimental
Placebo Comparator
Home-based training program
High-quality protein supplement
2 Anabolic interventions
3 Anabolic interventions
Placebo protein powder and omega-3
Home-based training program + protein placebo + omega-3 placebo
High-quality protein supplement + omega-3 placebo
Home-based training program and high quality protein supplement
Home-based training program, high-quality protein supplement and omega-3 fatty acids
Control group: protein placebo + omega-3 placebo