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Functional Changes and Power Training in Older Women. (F-POW)

Primary Purpose

Sarcopenia, Muscle Weakness

Status
Completed
Phase
Not Applicable
Locations
Canada
Study Type
Interventional
Intervention
power training
Sponsored by
University of Toronto
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Sarcopenia focused on measuring power training, high-speed training, high-velocity training, function, older adults, older women

Eligibility Criteria

65 Years - undefined (Older Adult)FemaleAccepts Healthy Volunteers

Inclusion Criteria:

  • females, 65 years of age
  • agree to the study protocol
  • give informed-consent to the proposed research study

Exclusion Criteria:

  • existing acute illness/disease (last six months)
  • diagnosed with myopathies
  • currently prescribed cardiovascular medications or drugs that may affect muscle mass and/or their response to exercise (thyroid medications, sedatives, beta blockers, some statins)
  • are diabetic
  • have uncontrolled hypertension
  • have been advised against participating in exercise by their doctor

Sites / Locations

  • Athletic Centre; 55 Harbord Street

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm Type

Experimental

Experimental

Experimental

No Intervention

Arm Label

Once a week

Twice a week

Thrice a week

wait-control

Arm Description

Group 1 will be invited to perform resistance training exercise 1 day/week. After a 2-week familiarization phase, participants will engage in power training (40% of 1-repetition maximum) for 12 weeks. Instructions include telling participants to lift the weight concentrically 'as fast as possible', with a lowering phase (eccentric) of 2-3 seconds. Participants will perform 3 x 12-14 repetitions per exercise per session. Primarily lower body equipment will be used, including leg press, knee extension/flexion, hip extension/flexion, and calf-raises.

Group 2 will be invited to perform resistance training exercise 2 days/week. After a 2-week familiarization phase, participants will engage in power training (40% of 1-repetition maximum) for 12 weeks. Instructions include telling participants to lift the weight concentrically 'as fast as possible', with a lowering phase (eccentric) of 2-3 seconds. Participants will perform 3 x 12-14 repetitions per exercise per session. Primarily lower body equipment will be used, including leg press, knee extension/flexion, hip extension/flexion, and calf-raises.

Group 3 will be invited to perform resistance training exercise 3 days/week. After a 2-week familiarization phase, participants will engage in power training (40% of 1-repetition maximum) for 12 weeks. Instructions include telling participants to lift the weight concentrically 'as fast as possible', with a lowering phase (eccentric) of 2-3 seconds. Participants will perform 3 x 12-14 repetitions per exercise per session. Primarily lower body equipment will be used, including leg press, knee extension/flexion, hip extension/flexion, and calf-raises.

Participants in this group will serve as controls prior to participating in power training in 1 of the above treatment groups. The control period will last as long as the exercise period, or 3 months. Controls will participate in the same testing time points as the exercisers (baseline, midpoint, and post-intervention).

Outcomes

Primary Outcome Measures

Change in Stair-climb power
The time needed to ascend a flight of stairs, converted to power (using body-weight and stair height)

Secondary Outcome Measures

Change in 400-meter walk test
The time needed to walk 400 meters (back and forth along a 20 meter course)
Change in Short Physical Performance Battery
A short test of balance, walking, and chair stand ability
Change in 30-second chair stand test
The number of chair stands possible in 30 seconds

Full Information

First Posted
August 17, 2015
Last Updated
November 5, 2020
Sponsor
University of Toronto
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1. Study Identification

Unique Protocol Identification Number
NCT02530723
Brief Title
Functional Changes and Power Training in Older Women.
Acronym
F-POW
Official Title
The Effects of Low-intensity Power Training on Strength, Power, and Functional Outcomes in Older, Community-dwelling Women.
Study Type
Interventional

2. Study Status

Record Verification Date
November 2020
Overall Recruitment Status
Completed
Study Start Date
September 2015 (Actual)
Primary Completion Date
July 16, 2018 (Actual)
Study Completion Date
July 16, 2018 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Toronto

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
Extending quality of life and attenuating functional decline is paramount in older adults. This study investigates the effects of low-intensity power-training in older women and its effects on functional outcomes.
Detailed Description
Resistance training has gained popularity in aging interventions since it is effective in countering the loss of muscle mass and strength with senescence. Traditionally, strength training (ST) protocols for the elderly have involved relatively heavy loads (70-80% of maximum force) with the focus being on increasing strength. There is some evidence of increased function after strength training albeit with inconsistent reports in the literature. More recently, several studies have designed resistance training programs that aim to increase power rather than strength, since findings indicate that measures of power are better predictors of physical function than measures of strength. In other words, improving power may be more beneficial to the elderly who are susceptible to functional limitations, mobility disability, and dependency. Since it is difficult to produce a great deal of power with increasing intensities, and lifting heavy loads may not be relevant to everyday functioning in the elderly, studies have investigated training for improvements in power rather than the traditional improvements in strength. The effects of power training (PT) versus ST on functional outcomes in older adults have varied, with some studies showing enhanced improvements in function, and others showing no difference in function compared to regular ST or compared to other interventions such as walking. Discrepancies might be the result of the variety of functional tests used, mode of training, variable frequency of sessions per week, differences in study length, and adults of varying functional status. It has been suggested that perhaps the standard 3-sessions-per-week frequency may not be optimal for the elderly. A previous investigation demonstrated that the effects from PT at 40% of the 1-repetition maximum (1RM: the highest amount that can be lifted once) in older adults was comparable to the effects from ST at 80% 1RM with improvements being similar between the two modes despite the lower daily ratings of perceived exertion (RPE) reported with PT (PT: RPE for leg press (12.2) and knee extension (14.6) vs ST: RPE for leg press (15.1) and knee extension (17)). Therefore, an 'easier' exercise training experience did not result in sacrifices in gains of strength and power. In theory, these factors (lighter loads, lower perceived exertions, similar strength and power gains) could affect adherence to exercise during and after a research-related exercise intervention has been completed and thus are important considerations in the design of a training program. The purpose of this research is to investigate the effects of low-intensity (40% 1RM) PT on functional outcomes in older women.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Sarcopenia, Muscle Weakness
Keywords
power training, high-speed training, high-velocity training, function, older adults, older women

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Factorial Assignment
Model Description
With 3 groups and a wait-control group, our general design will include 4 (group) x 2 (baseline and post-study) and 4 (group) x 3 (baseline, midpoint, and post-study) analyses. We may also conduct one-way ANOVA analyses as problems with normality in the data are apparent.
Masking
Outcomes Assessor
Masking Description
Functional testers are masked to what group the participants are in (control, Exercise Group I, II, or III). All testers are masked during baseline testing.
Allocation
Randomized
Enrollment
50 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Once a week
Arm Type
Experimental
Arm Description
Group 1 will be invited to perform resistance training exercise 1 day/week. After a 2-week familiarization phase, participants will engage in power training (40% of 1-repetition maximum) for 12 weeks. Instructions include telling participants to lift the weight concentrically 'as fast as possible', with a lowering phase (eccentric) of 2-3 seconds. Participants will perform 3 x 12-14 repetitions per exercise per session. Primarily lower body equipment will be used, including leg press, knee extension/flexion, hip extension/flexion, and calf-raises.
Arm Title
Twice a week
Arm Type
Experimental
Arm Description
Group 2 will be invited to perform resistance training exercise 2 days/week. After a 2-week familiarization phase, participants will engage in power training (40% of 1-repetition maximum) for 12 weeks. Instructions include telling participants to lift the weight concentrically 'as fast as possible', with a lowering phase (eccentric) of 2-3 seconds. Participants will perform 3 x 12-14 repetitions per exercise per session. Primarily lower body equipment will be used, including leg press, knee extension/flexion, hip extension/flexion, and calf-raises.
Arm Title
Thrice a week
Arm Type
Experimental
Arm Description
Group 3 will be invited to perform resistance training exercise 3 days/week. After a 2-week familiarization phase, participants will engage in power training (40% of 1-repetition maximum) for 12 weeks. Instructions include telling participants to lift the weight concentrically 'as fast as possible', with a lowering phase (eccentric) of 2-3 seconds. Participants will perform 3 x 12-14 repetitions per exercise per session. Primarily lower body equipment will be used, including leg press, knee extension/flexion, hip extension/flexion, and calf-raises.
Arm Title
wait-control
Arm Type
No Intervention
Arm Description
Participants in this group will serve as controls prior to participating in power training in 1 of the above treatment groups. The control period will last as long as the exercise period, or 3 months. Controls will participate in the same testing time points as the exercisers (baseline, midpoint, and post-intervention).
Intervention Type
Other
Intervention Name(s)
power training
Other Intervention Name(s)
resistance training, high-speed training, high-velocity training
Intervention Description
Resistance training machines with CAM devices will be used for training.
Primary Outcome Measure Information:
Title
Change in Stair-climb power
Description
The time needed to ascend a flight of stairs, converted to power (using body-weight and stair height)
Time Frame
baseline, 6 weeks, 12 weeks
Secondary Outcome Measure Information:
Title
Change in 400-meter walk test
Description
The time needed to walk 400 meters (back and forth along a 20 meter course)
Time Frame
baseline, 6 weeks, 12 weeks
Title
Change in Short Physical Performance Battery
Description
A short test of balance, walking, and chair stand ability
Time Frame
baseline, 6 weeks, 12 weeks
Title
Change in 30-second chair stand test
Description
The number of chair stands possible in 30 seconds
Time Frame
baseline, 6 weeks, 12 weeks

10. Eligibility

Sex
Female
Minimum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: females, 65 years of age agree to the study protocol give informed-consent to the proposed research study Exclusion Criteria: existing acute illness/disease (last six months) diagnosed with myopathies currently prescribed cardiovascular medications or drugs that may affect muscle mass and/or their response to exercise (thyroid medications, sedatives, beta blockers, some statins) are diabetic have uncontrolled hypertension have been advised against participating in exercise by their doctor
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Catherine E Amara, Ph.D
Organizational Affiliation
University of Toronto; Faculty of Kinesiology and Physical Education
Official's Role
Study Director
Facility Information:
Facility Name
Athletic Centre; 55 Harbord Street
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5S 2W6
Country
Canada

12. IPD Sharing Statement

Citations:
PubMed Identifier
8190152
Citation
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Citation
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Results Reference
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Citation
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Results Reference
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Citation
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Functional Changes and Power Training in Older Women.

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