Hyperhidrosis, Developing a Treatment Approach Aims 1 & 2
Hyperhidrosis
About this trial
This is an interventional treatment trial for Hyperhidrosis focused on measuring amputation, amputations, sweating, residual limb, service members, civilians
Eligibility Criteria
Aim 1 and Aim 2
Inclusion Criteria:
- Provision of signed and dated informed consent form (ICF)
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Male or female, age 18 or older
- Have a prosthetic device
- In good general health as evidenced by medical history
- If subject is currently using aluminum chloride participant must be discontinued for at least one week prior to participation in the study.
Exclusion Criteria:
- Open sores or wounds on the residual limb
- Known sensitivity or allergy to iodine
- Known sensitivity to antiperspirant, aluminum chloride hexahydrate
Sites / Locations
- George E. Wahlen Department of Veterans Affairs Medical Center
- University of Utah
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Active Comparator
Placebo Comparator AIM 1
Aluminum Chloride vs Placebo in Amputees
Aim 1: Demonstration of a strong association of the Sweating Intensity Visual Scale (SIVS) score with the HDSS would provide validation for use of the SIVS in interpreting the iodine-starch test and would establish the value of the iodine-starch test in clinical practice guidelines for diagnosing hyperhidrosis in amputees, just as it is in dermatology practice.
Aim 2: The investigators will have completed the first clinical trial of Aluminum Chloride for residual limb hyperhidrosis. The investigators will then have a solid foundation of data that demonstrates the rates of adverse effects such as skin irritation, and rates and magnitudes of improvement in subjective and objective measures of sweating.