Hypertension in Young Adults Trial
Hypertension
About this trial
This is an interventional treatment trial for Hypertension
Eligibility Criteria
Inclusion Criteria:
- 18-35 years of age
- Diagnosis of hypertension or receiving anti-hypertensive therapy OR Has clinical BP readings >130/80 mmHg that would meet the definition of hypertension and have home BP readings >=125/80 mmHg
Exclusion Criteria:
- are or are planning to become pregnant, due to inability to take multiple classes of anti- hypertensive agents
- are marginally housed, due to concerns regarding routine follow-up
- are actively participating in a different interventional trial that may affect blood pressure
- are unwilling to consent to participate
- institutionalized individuals or prisoners
- are actively abusing illicit drugs or alcohol
- have a history of poor or doubtful compliance (e.g., frequently missed appointments)
- are already taking ≥3 anti-hypertensive medications (any classes, including diuretics)
- have cognitive impairment prohibiting participation in the study
- History of allergy to any of the randomized medications
- Serum potassium >5.5 meq/L at the screening visit
- BP > 160/100 mmHg in clinic (stage II hypertension), regardless of whether patient is on therapy
- eGFR < 60 mL/min/1.73 m2
Sites / Locations
- University of California San FranciscoRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Arm 9
Active Comparator
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Amlodipine 2.5 mg + Home BP monitoring with cuffed device
Chlorthalidone 12.5 mg + Home BP monitoring with cuffed device
Losartan 12.5 mg daily + home BP monitoring with cuffed device
amlodipine 2.5 mg daily + home BP monitoring with patch
Chlorthalidone 12.5 mg daily + home BP monitoring with patch
Losartan 12.5 mg daily + home BP monitoring with patch
amlodipine 2.5 mg daily + home BP monitoring with watch
chlorthalidone 12.5 mg daily + home BP monitoring with watch
losartan 12.5 mg daily + home BP monitoring with watch
Use of at least the minimum dose of amlodipine and use of a home BP monitoring device for BP monitoring
Use of at least the minimum dose of chlorthalidone and use of a home BP monitoring device for BP monitoring
Use of at least the minimum dose of losartan and use of a home BP monitoring cuffed device only for BP monitoring
Use of at least the minimum dose of this agent and use of a home BP monitoring device only + a patch for BP monitoring
Use of at least the minimum dose of this agent and use of a home BP monitoring device only + a patch for BP monitoring
Use of at least the minimum dose of this agent and use of a home BP monitoring device only + a patch for BP monitoring
Use of at least the minimum dose of this agent and use of a home BP monitoring device only + a watch for BP monitoring
Use of at least the minimum dose of this agent and use of a home BP monitoring device only + a watch for BP monitoring
Use of at least the minimum dose of this agent and use of a home BP monitoring device only + a watch for BP monitoring