Impact of Chewing Gum With CPP-ACP on Tooth Mineralisation in Situ

This is an interventional basic science trial for Tooth Demineralization focused on measuring casein phosphopeptide-amorphous calcium phosphate, CPP-ACP, in situ appliance, Transverse Microradiography, TMR, Recaldent, Tooth Remineralization Read More

Inclusion Criteria:

• Healthy adults aged between 18 and 55 years old (inclusive)
• Subject has read, signed and received a copy of the Informed Consent prior to initiation of study procedures
• Subject is willing and able to follow the study directions, to participate in the study, returning for all specified visits at their appointed time, and to use the product as per instructions
• Subject is in good general health based on medical history and oral soft and hard tissue examination
• Subject with normal salivary flow (unstimulated flow rate ≥0.3ml/min)
• Subject not disliking the taste of the SFG provided
• Subject with stable dietary habits and willing to consume 3 main meals per day with two extra-prandial intakes
• Healthy adults with a BMI value between 20 and 30 kg/m²

Exclusion Criteria:

General criteria

• Subject under legal protection measure
• Subject deprived of liberty by a court or an administrative decision
• Subject currently participating in another study or being in the exclusion period of another study

Biological, therapeutic and medical criteria

• Subject is pregnant, lactating or intend to become pregnant during the course of the clinical study based on oral interview only, as pregnancy may interfere with the outcome of the study
• Subject has a systemic health condition and disorders (such as diabetes HIV positive, AIDS and systemic lupus erythematosis) that could affect the outcome of the study at the discretion of the Investigator
• Any active oral condition, such as caries, periodontal disease, chronic dental neglect or any oral pathology including xerostomia determined by oral evaluation and subject history that in the opinion of the dental examiner could affect the outcome of the study
• Subject has full or partial dentures or any orthodontic appliances (i.e. braces or use of night guards) or tongue or mouth piercing
• Use of other oral care products except the one provided by study team during the wash out period or during the treatment period
• Participation in a research study within the last 30 days
• Subjects treated with antibiotics during the last 30 days or other medications, which in the opinion of the Investigator might influence the study outcome
• Subjects with a history of sensitivity or allergies to ingredients in the study products or allergens present in the production facility (facility which also handles milk, egg, soy, peanut, tree nuts, wheat, fish, crustacean, mollusk, lupine, sesame, seeds, sulphites)Subjects with any concurrent illness, such as a cold, flu, upper respiratory infection, sinusitis or other infectious conditions
• Subjects under a restrictive diet or with a planned weight loss program during the study
• Subjects with severe eating disorders (e.g. anorexia nervosa, binge eating disorder and bulimia)
• Subjects without stable dietary habits or with specific dieting regime, for instance Atkins diet, gluten-free diet and additional specific diets at the discretion of the Investigator
• Subjects who smokes or vapes